Siem Reap Cruise Departures
Cruises that depart from Asia/Far East: Cambodia: Siem Reap
Cruises that visit Siem Reap
See all River Cruises that depart from Siem Reap
7 Night - Riches of the Mekong
Starting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 13, Apr 27, Aug 17, Aug 31, Sep 14, Sep 28, Oct 12, Oct 26, Nov 9, Nov 23, Dec 7, 2027: Jan 4, Jan 18, Feb 1, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, Aug 16, Aug 30, Sep 13, Sep 27, Oct 11, More...9 Night - Riches of the Mekong with Ho Chi Minh Post-Cruise
Starting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 13, Apr 27, 2027: Jan 4, Jan 18, Feb 1, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, More...
12 Night - Treasures of the Mekong
Starting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec / Cai Be, Mekong Cruise / Ho Chi Minh City, Ho Chi Minh City
2026 Sails: May 9, Sep 19, Oct 3, Nov 28, More...14 Night - Treasures of the Mekong Meandering Cruise
Starting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Kampong Cham / Angkor Ban, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec, Cai Be, Mekong Cruise / Ho Chi Minh City, Ho Chi Minh City
2026 Sails: Jul 27, Aug 14, Sep 1, Dec 14, More...12 Night - Temple Discovery and Meandering Along the Mekong Cruise
Starting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Kampong Cham / Angkor Ban, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec, Cai Be, Mekong Cruise / Ho Chi Minh City
2026 Sails: Jul 27, Aug 14, Sep 1, Dec 14, More...
12 Night - Fascinating Vietnam, Cambodia & the Mekong River (Southbound)
Starting in Siem Reap, Cambodia, Siem Reap, Siem Reap / Phnom Penh (Embarkation), Wat Hanchey / Angkor Ban, Kampong Tralach / Konpong Louang / Phnom Penh, Phnom Penh, Border Crossing / Chau Doc, Vietnam, Long Khanh / Cu Lao Gieng, Vinh Long, Ho Chi Minh City (Disembarkation), Ho Chi Minh City Excursion to Cu Chi Tunnels, Ho Chi Minh City
2026 Sails: Aug 10, Aug 24, Sep 7, Sep 21, Nov 2, Nov 16, Nov 30, More...15 Night - Fascinating Vietnam, Cambodia & the Mekong River with Bangkok (Southbound)
Starting in Siem Reap, Cambodia, Siem Reap, Siem Reap / Phnom Penh (Embarkation), Wat Hanchey / Angkor Ban, Kampong Tralach / Konpong Louang / Phnom Penh, Phnom Penh, Border Crossing / Chau Doc, Vietnam, Long Khanh / Cu Lao Gieng, Vinh Long, Ho Chi Minh City (Disembarkation), Ho Chi Minh City Excursion to Cu Chi Tunnels, Ho Chi Minh City / Bangkok, Thailand, Bangkok
2026 Sails: Aug 10, Aug 24, Sep 7, Sep 21, Nov 2, Nov 16, Nov 30, More...
14 Night - Wonders of Cambodia, Vietnam & the Mekong
Starting in Arrive Siem Reap, Siem Reap, Siem Reap / Peam Chi Korng / Mekong Cruise, Angkor Ban / Phnom Penh, Phnom Penh, Phnom Penh / Cross Cambodia / Vietnam Border, Tan Chau, An Long / Gieng Island, My An Hung / Sa Dec, Ben Tre, Cho Gao canal / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Aug 18, Sep 5, Dec 16, 2027: Jan 3, Aug 17, Sep 4, Dec 17, More...10 Night - Luxury Mekong and Temple Discovery Cruise
Starting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec / Cai Be, Mekong Cruise / Ho Chi Minh City
2026 Sails: Sep 19, Oct 3, Oct 17, Nov 28, More...12 Night - Wonders of Cambodia, Vietnam & the Mekong
Starting in Arrive Siem Reap, Siem Reap, Siem Reap / Rokar Koang / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Sep 23, Oct 7, Nov 4, Nov 18, Dec 2, 2027: Jan 20, Feb 3, Feb 17, Mar 3, Mar 17, Mar 31, Apr 14, Apr 28, May 12, Oct 6, Oct 20, Nov 3, Nov 17, More...
Cruises that depart from Asia/Far East: Cambodia: Siem Reap
Cruises that visit Siem Reap
See all River Cruises that depart from Siem Reap
Click on a cruise ship itinerary sailing from Siem Reap (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Siem Reap), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Riches of the MekongStarting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 13, Apr 27, Aug 17, Aug 31, Sep 14, Sep 28, Oct 12, Oct 26, Nov 9, Nov 23, Dec 7, 2027: Jan 4, Jan 18, Feb 1, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, Aug 16, Aug 30, Sep 13, Sep 27, Oct 11, More...
9 Night - Riches of the Mekong with Ho Chi Minh Post-CruiseStarting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 13, Apr 27, 2027: Jan 4, Jan 18, Feb 1, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, More...
12 Night - Treasures of the MekongStarting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec / Cai Be, Mekong Cruise / Ho Chi Minh City, Ho Chi Minh City
2026 Sails: May 9, Sep 19, Oct 3, Nov 28, More...
14 Night - Treasures of the Mekong Meandering CruiseStarting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Kampong Cham / Angkor Ban, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec, Cai Be, Mekong Cruise / Ho Chi Minh City, Ho Chi Minh City
2026 Sails: Jul 27, Aug 14, Sep 1, Dec 14, More...
12 Night - Temple Discovery and Meandering Along the Mekong CruiseStarting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Kampong Cham / Angkor Ban, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec, Cai Be, Mekong Cruise / Ho Chi Minh City
2026 Sails: Jul 27, Aug 14, Sep 1, Dec 14, More...
12 Night - Fascinating Vietnam, Cambodia & the Mekong River (Southbound)Starting in Siem Reap, Cambodia, Siem Reap, Siem Reap / Phnom Penh (Embarkation), Wat Hanchey / Angkor Ban, Kampong Tralach / Konpong Louang / Phnom Penh, Phnom Penh, Border Crossing / Chau Doc, Vietnam, Long Khanh / Cu Lao Gieng, Vinh Long, Ho Chi Minh City (Disembarkation), Ho Chi Minh City Excursion to Cu Chi Tunnels, Ho Chi Minh City
2026 Sails: Aug 10, Aug 24, Sep 7, Sep 21, Nov 2, Nov 16, Nov 30, More...
15 Night - Fascinating Vietnam, Cambodia & the Mekong River with Bangkok (Southbound)Starting in Siem Reap, Cambodia, Siem Reap, Siem Reap / Phnom Penh (Embarkation), Wat Hanchey / Angkor Ban, Kampong Tralach / Konpong Louang / Phnom Penh, Phnom Penh, Border Crossing / Chau Doc, Vietnam, Long Khanh / Cu Lao Gieng, Vinh Long, Ho Chi Minh City (Disembarkation), Ho Chi Minh City Excursion to Cu Chi Tunnels, Ho Chi Minh City / Bangkok, Thailand, Bangkok
2026 Sails: Aug 10, Aug 24, Sep 7, Sep 21, Nov 2, Nov 16, Nov 30, More...
14 Night - Wonders of Cambodia, Vietnam & the MekongStarting in Arrive Siem Reap, Siem Reap, Siem Reap / Peam Chi Korng / Mekong Cruise, Angkor Ban / Phnom Penh, Phnom Penh, Phnom Penh / Cross Cambodia / Vietnam Border, Tan Chau, An Long / Gieng Island, My An Hung / Sa Dec, Ben Tre, Cho Gao canal / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Aug 18, Sep 5, Dec 16, 2027: Jan 3, Aug 17, Sep 4, Dec 17, More...
10 Night - Luxury Mekong and Temple Discovery CruiseStarting in Siem Reap, Siem Reap / Mekong Cruise, Wat Hanchey / Kampong Cham, Angkor Ban / Silk Island / Phnom Penh, Phnom Penh, Phnom Penh / Border Crossing / Tan Chau, Tan Chau, Sa Dec / Cai Be, Mekong Cruise / Ho Chi Minh City
2026 Sails: Sep 19, Oct 3, Oct 17, Nov 28, More...
12 Night - Wonders of Cambodia, Vietnam & the MekongStarting in Arrive Siem Reap, Siem Reap, Siem Reap / Rokar Koang / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Sep 23, Oct 7, Nov 4, Nov 18, Dec 2, 2027: Jan 20, Feb 3, Feb 17, Mar 3, Mar 17, Mar 31, Apr 14, Apr 28, May 12, Oct 6, Oct 20, Nov 3, Nov 17, More...
