Siem Reap Cruise Departures
Cruises that depart from Asia/Far East: Cambodia: Siem Reap
Cruises that visit Siem Reap
See all River Cruises that depart from Siem Reap
12 Night - Riches of the Mekong with Siem Reap Pre-Cruise and Ho Chi Minh City Post-Cruise
Starting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 2, Feb 13, Mar 13, Mar 27, Apr 10, Apr 24, 2027: Jan 1, Jan 29, Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...10 Night - Riches of the Mekong with Siem Reap Pre-Cruise
Starting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 2, Feb 13, Mar 13, Mar 27, Apr 10, Apr 24, 2027: Jan 1, Jan 29, Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...7 Night - Riches of the Mekong
Starting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 5, Feb 16, Mar 16, Mar 30, Apr 13, Apr 27, Aug 17, Aug 31, Sep 14, Sep 28, Oct 12, Oct 26, Nov 9, Nov 23, Dec 7, 2027: Jan 4, Jan 18, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, More...9 Night - Riches of the Mekong with Ho Chi Minh Post-Cruise
Starting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 5, Feb 16, Mar 16, Mar 30, Apr 13, Apr 27, 2027: Jan 4, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, More...
12 Night - Sailing Vietnam and Cambodia's Mekong River Aboard The
Starting in Siem Reap, Cambodia, Angkor, Steung Trang / Embark Ship, Wat Hanchey or Koh Dach / Angkor Ban, Kampong Chhnang / Kampong Tralach, Phnom Penh, Cruising the Mekong, Chau Doc or Tan Chau, Vietnam, Sa Dec / Cai Be, My Tho / Disembark Ship / Saigon (Ho Chi Minh City), Saigon
2026 Sails: Jan 14, Jan 28, 2027: Jan 13, Feb 24, More...
3 Night - Phnom Penh and Siem Reap
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Jan 18, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, More...7 Night - Classic Mekong
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Jan 18, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, 2027: Jan 23, Mar 6, Mar 20, Oct 30, Nov 13, Dec 25, 2028: Jan 8, Jan 22, Feb 5, Feb 19, Mar 4, Mar 18, Apr 1, More...
3 Night - Phnom Penh and Siem Reap
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Jan 24, Mar 7, Mar 21, More...7 Night - Classic Mekong
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Jan 24, Mar 7, Mar 21, Oct 24, Nov 21, Dec 5, Dec 19, 2027: Jan 2, Feb 13, Mar 13, Oct 9, Oct 23, Nov 6, Nov 20, 2028: Jan 1, Jan 15, Jan 29, Feb 12, Feb 26, Mar 11, Mar 25, Apr 8, Apr 22, More...
12 Night - Wonders of Cambodia, Vietnam & the Mekong
Starting in Arrive Siem Reap, Siem Reap, Siem Reap / Prek KDam / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Feb 4, Feb 18, Mar 4, Mar 18, Apr 1, Apr 15, Apr 29, May 13, More...
Cruises that depart from Asia/Far East: Cambodia: Siem Reap
Cruises that visit Siem Reap
See all River Cruises that depart from Siem Reap
Click on a cruise ship itinerary sailing from Siem Reap (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Siem Reap), please visit: Cruise Search or try our Virtual Cruise Advisor™.
12 Night - Riches of the Mekong with Siem Reap Pre-Cruise and Ho Chi Minh City Post-CruiseStarting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 2, Feb 13, Mar 13, Mar 27, Apr 10, Apr 24, 2027: Jan 1, Jan 29, Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...
10 Night - Riches of the Mekong with Siem Reap Pre-CruiseStarting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 2, Feb 13, Mar 13, Mar 27, Apr 10, Apr 24, 2027: Jan 1, Jan 29, Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...
7 Night - Riches of the MekongStarting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 5, Feb 16, Mar 16, Mar 30, Apr 13, Apr 27, Aug 17, Aug 31, Sep 14, Sep 28, Oct 12, Oct 26, Nov 9, Nov 23, Dec 7, 2027: Jan 4, Jan 18, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, More...
9 Night - Riches of the Mekong with Ho Chi Minh Post-CruiseStarting in Siem Reap, Kampong Cham, Angkor Ban, Oknhatey Village, Phnom Penh, Oudong, Phnom Penh, Border Crossing, Tan Chau, Sa Dec, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Jan 5, Feb 16, Mar 16, Mar 30, Apr 13, Apr 27, 2027: Jan 4, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, Apr 12, Apr 26, More...
12 Night - Sailing Vietnam and Cambodia's Mekong River Aboard TheStarting in Siem Reap, Cambodia, Angkor, Steung Trang / Embark Ship, Wat Hanchey or Koh Dach / Angkor Ban, Kampong Chhnang / Kampong Tralach, Phnom Penh, Cruising the Mekong, Chau Doc or Tan Chau, Vietnam, Sa Dec / Cai Be, My Tho / Disembark Ship / Saigon (Ho Chi Minh City), Saigon
2026 Sails: Jan 14, Jan 28, 2027: Jan 13, Feb 24, More...
3 Night - Phnom Penh and Siem ReapStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Jan 18, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, More...
7 Night - Classic MekongStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Jan 18, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, 2027: Jan 23, Mar 6, Mar 20, Oct 30, Nov 13, Dec 25, 2028: Jan 8, Jan 22, Feb 5, Feb 19, Mar 4, Mar 18, Apr 1, More...
3 Night - Phnom Penh and Siem ReapStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Jan 24, Mar 7, Mar 21, More...
7 Night - Classic MekongStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Jan 24, Mar 7, Mar 21, Oct 24, Nov 21, Dec 5, Dec 19, 2027: Jan 2, Feb 13, Mar 13, Oct 9, Oct 23, Nov 6, Nov 20, 2028: Jan 1, Jan 15, Jan 29, Feb 12, Feb 26, Mar 11, Mar 25, Apr 8, Apr 22, More...
12 Night - Wonders of Cambodia, Vietnam & the MekongStarting in Arrive Siem Reap, Siem Reap, Siem Reap / Prek KDam / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Feb 4, Feb 18, Mar 4, Mar 18, Apr 1, Apr 15, Apr 29, May 13, More...
