Siem Reap Cruise Departures
Cruises that depart from Asia/Far East: Cambodia: Siem Reap
Cruises that visit Siem Reap
See all River Cruises that depart from Siem Reap
3 Night - Phnom Penh and Siem Reap
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Feb 15, Mar 1, Mar 15, Mar 29, More...7 Night - Classic Mekong
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Feb 15, Mar 1, Mar 15, Mar 29, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, 2027: Mar 6, Mar 20, Oct 30, Nov 13, Dec 25, 2028: Jan 8, Jan 22, Feb 5, Feb 19, Mar 4, Mar 18, Apr 1, Apr 15, More...
12 Night - Wonders of Cambodia, Vietnam & the Mekong
Starting in Arrive Siem Reap, Siem Reap, Siem Reap / Prek KDam / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Feb 18, Mar 18, Apr 1, Apr 15, Apr 29, May 13, More...10 Night - Enchanting Mekong and Siem Reap
Starting in Arrive Siem Reap, Siem Reap, Siem Reap / Prek KDam / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation
2026 Sails: Feb 18, More...
7 Night - Classic Mekong
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Feb 22, Mar 8, Mar 22, Nov 11, More...3 Night - Phnom Penh and Siem Reap
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Feb 22, Mar 8, Mar 22, More...
3 Night - Phnom Penh and Siem Reap
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Mar 7, Mar 21, More...7 Night - Classic Mekong
Starting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Mar 7, Mar 21, Oct 24, Nov 21, Dec 5, 2027: Jan 2, Feb 13, Mar 13, Oct 9, Oct 23, Nov 20, 2028: Jan 1, Jan 15, Jan 29, Feb 12, Feb 26, Mar 11, Mar 25, Apr 8, Apr 22, More...
12 Night - Riches of the Mekong with Siem Reap Pre-Cruise and Ho Chi Minh City Post-Cruise
Starting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 10, Apr 24, 2027: Jan 1, Jan 15, Jan 29, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...10 Night - Riches of the Mekong with Siem Reap Pre-Cruise
Starting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 10, Apr 24, 2027: Jan 1, Jan 15, Jan 29, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...
Cruises that depart from Asia/Far East: Cambodia: Siem Reap
Cruises that visit Siem Reap
See all River Cruises that depart from Siem Reap
Click on a cruise ship itinerary sailing from Siem Reap (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Siem Reap), please visit: Cruise Search or try our Virtual Cruise Advisor™.
3 Night - Phnom Penh and Siem ReapStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Feb 15, Mar 1, Mar 15, Mar 29, More...
7 Night - Classic MekongStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Feb 15, Mar 1, Mar 15, Mar 29, Oct 31, Nov 14, Nov 28, Dec 12, Dec 26, 2027: Mar 6, Mar 20, Oct 30, Nov 13, Dec 25, 2028: Jan 8, Jan 22, Feb 5, Feb 19, Mar 4, Mar 18, Apr 1, Apr 15, More...
12 Night - Wonders of Cambodia, Vietnam & the MekongStarting in Arrive Siem Reap, Siem Reap, Siem Reap / Prek KDam / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation, Ho Chi Minh City, Depart Ho Chi Minh City
2026 Sails: Feb 18, Mar 18, Apr 1, Apr 15, Apr 29, May 13, More...
10 Night - Enchanting Mekong and Siem ReapStarting in Arrive Siem Reap, Siem Reap, Siem Reap / Prek KDam / Mekong Cruise, Kampong Tralach / Oudong / Phnom Penh, Phnom Penh, Cross Vietnam / Cambodia Border / Tan Chau, Gieng Island / My An Hung, Sa Dec / Cai Be, My Tho / Ho Chi Minh City, Ho Chi Minh City Disembarkation
2026 Sails: Feb 18, More...
7 Night - Classic MekongStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Feb 22, Mar 8, Mar 22, Nov 11, More...
3 Night - Phnom Penh and Siem ReapStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Feb 22, Mar 8, Mar 22, More...
3 Night - Phnom Penh and Siem ReapStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh Disembarkation
2026 Sails: Mar 7, Mar 21, More...
7 Night - Classic MekongStarting in Siem Reap to the Mekong, Peam Chi Korng and Pak Russei Crafts, Tonle Sap River, Phnom Penh, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Mar 7, Mar 21, Oct 24, Nov 21, Dec 5, 2027: Jan 2, Feb 13, Mar 13, Oct 9, Oct 23, Nov 20, 2028: Jan 1, Jan 15, Jan 29, Feb 12, Feb 26, Mar 11, Mar 25, Apr 8, Apr 22, More...
12 Night - Riches of the Mekong with Siem Reap Pre-Cruise and Ho Chi Minh City Post-CruiseStarting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 10, Apr 24, 2027: Jan 1, Jan 15, Jan 29, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...
10 Night - Riches of the Mekong with Siem Reap Pre-CruiseStarting in Siem Reap, Port Clarence, Atka, Phnom Penh, Tan Chau, Safford, Cai Be, My Tho, Ho Chi Minh City
2026 Sails: Apr 10, Apr 24, 2027: Jan 1, Jan 15, Jan 29, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...
