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Santos Cruise Departures

Cruises that depart from South America: Brazil: Santos

Cruises that visit Santos

Click on a cruise ship itinerary sailing from Santos (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santos), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Costa Cruise Lines, Costa Diadema
Costa Diadema Cruises17 Night - Transatlantic from Santos
Starting in Santos, Rio De Janeiro, Salvador Bahia, Maceio, Praia, Santa Cruz de Tenerife, Casablanca, Cadice, Lisbon
2026 Sails: Apr 19, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema Cruises27 Night - Transatlantic from Santos
Starting in Santos, Rio De Janeiro, Salvador Bahia, Maceio, Praia, Santa Cruz de Tenerife, Casablanca, Cadice, Lisbon, Leixoes, Vigo, Le Havre, Southampton, Zeebrugge, Kiel, Copenhagen
2026 Sails: Apr 19, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema Cruises26 Night - Transatlantic from Santos
Starting in Santos, Brazil, Rio de Janeiro, Brazil, Salvador Bahia, Brazil, Maceio, Brazil, Praia, Santa Cruz de Tenerife, Casablanca, Morocco, Cadiz, Spain, Lisbon, Portugal, Leixoes, Portugal, Vigo, Spain, Le Havre, France, Southampton (UK), Bruges, Belgium, Kiel, Germany
2026 Sails: Apr 19, More...
MSC Cruises, MSC Musica
MSC Musica Cruise Ship4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Ilha Grande, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 12, Nov 26, Dec 6, More...
MSC Cruises, MSC Musica
MSC Musica Cruise Ship4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilha Grande, Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 16, More...
MSC Cruises, MSC Musica
MSC Musica Cruise Ship3 Night - Ssz
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 20, Dec 17, 2027: Feb 9, Feb 16, Mar 29, More...
MSC Cruises, MSC Musica
MSC Musica Cruise Ship3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 23, More...
MSC Cruises, MSC Musica
MSC Musica Cruise Ship3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 30, Dec 10, 2027: Jan 22, Jan 29, Feb 26, Mar 5, Mar 12, Mar 26, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa Cruises3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 2, More...
MSC Cruises, MSC Musica
MSC Musica Cruise Ship3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 3, More...

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Santos Cruise Departures