Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

7 Night - Southern Italy Dream Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Porto Cervo, Sardinia, Positano, Amalfi, Lipari, Aeolian Islands, Taormina (Mount Etna) Sicily, Valletta
2026 Sails: Sep 5, More...

Explora Journeys, EXPLORA I

7 Night - A Journey of Antique Treasures to Sumptuous Catalan
Starting in Rome (Civitavecchia), Porto Santo Stefano (Argentario), Monte Carlo, Saint-Tropez, Valencia, Palma De Mallorca, Barcelona
2026 Sails: Sep 7, More...

Royal Caribbean International (RCL), RCL Brilliance of the Seas

7 Night - Italy, Spain & French Riviera
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Santa Margherita, Italy, Cannes, France, Provence (Marseille), France, Valencia, Spain, Barcelona, Spain
2026 Sails: Sep 7, More...

Oceania Cruises, Oceania Sirena

10 Night - Coastal Mediterranean Gems
Starting in Rome (Civitavecchia), Florence / Pisa / Tuscany (Livorno), Cinque Terre (La Spezia), Villefranche, Provence (Marseille), Barcelona, Valencia, Alicante, Palma De Mallorca, Valletta
2026 Sails: Sep 10, More...

Ritz-Carlton Yacht Collection, Evrima

7 Night - Rome (Civitavecchia) / Athens (Piraeus)
Starting in Rome (Civitavecchia), Sorrento, Taormina (Naxos), Sicily, Chania (Souda), Crete, Santorini, Milos, Athens (Piraeus)
2026 Sails: Sep 12, More...

Oceania Cruises, Oceania Nautica

Deal link -> Special

10 Night - Dazzling Mediterranean
Starting in Rome (Civitavecchia), Sorrento / Capri, Messina (Sicily), Valletta, Dubrovnik, Croatia, Kotor, Corfu, Katakolon, Santorini, Athens (Piraeus)
2026 Sails: Sep 13, More...

Oceania Cruises, Oceania Allura

Deal link -> Special

12 Night - Artifacts & Antiquities
Starting in Rome (Civitavecchia), Amalfi / Positano, Naples / Pompeii, Cagliari (Sardinia), Trapani (Sicily), Valletta, Agios Nikolaos (Crete), Santorini, Ephesus (Kusadasi), Skiathos, Istanbul
2026 Sails: Sep 14, More...

Viking Ocean, Viking Sea

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Tarragona
2026 Sails: Sep 15, More...

Windstar Cruise Tours, Star Legend Cruise Tours

9 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise Tour
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Sep 19, More...

Windstar Cruises, Star Legend

14 Night - Star Collector : Mediterranean Masterpieces of Italy & Northern Greece
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Kusadasi, Kavala, Greece, Thessaloniki, Greece, Volos, Greece, Skopelos, Greece, Athens, Greece
2026 Sails: Sep 19, More...

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