Rome Cruise Departures
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
See all River Cruises that depart from Rome
7 Night - Mediterranean Holiday Cruise : Florence, Mahon & Palma
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Mahon, Menorca, Palma, Majorca, Barcelona
2026 Sails: Dec 22, More...17 Night - Mediterranean & Iberian Combination Cruise : Florence, Malaga & Seville
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Mahon, Menorca, Palma, Majorca, Barcelona, Cartagena ES, Malaga, Casablanca, Tangier, Cadiz, Seville, Lisbon
2026 Sails: Dec 22, More...
7 Night - Amalfi Coast, Africa & Iberia
Starting in Rome (Civitavecchia), Naples, Scenic Sailing Stromboli, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona
2026 Sails: Dec 23, More...
14 Night - Ancient Mediterranean Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Dec 30, 2027: Feb 24, 2028: Feb 17, More...
7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2027 Sails: Jan 3, Feb 15, Dec 30, More...
10 Night - Invitation to Iberia
Starting in Rome (Civitavecchia), Florence / Pisa / Tuscany (Livorno), Portofino, Nice, Provence (Marseille), Barcelona, Alicante, Granada (Motril), Seville (Cadiz), Lisbon
2027 Sails: Jan 4, More...
14 Night - Mediterranean & Adriatic Odyssey
Starting in Rome (Civitavecchia), Naples, Sicily (Syracuse IT), Sail the Mediterranean Sea, Bari, Split, Zadar, Venice (Fusina), Ancona, Dubrovnik, Croatia, Corfu (Kerkyra), Kalamata, Crete (Souda Bay), Athens (Piraeus)
2027 Sails: Jan 5, More...
7 Night - Amalfi Coast, Africa & Iberia
Starting in Rome (Civitavecchia), Salerno, Palermo, Sicily, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona
2027 Sails: Jan 5, Feb 16, Mar 2, Mar 16, Nov 13, Dec 12, 2028: Mar 16, More...14 Night - Jewels of the Mediterranean
Starting in Rome (Civitavecchia), Salerno, Palermo, Sicily, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona, Sete, Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia)
2027 Sails: Jan 5, Mar 2, Mar 16, More...14 Night - Ancient Mediterranean Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2027 Sails: Jan 6, More...
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
See all River Cruises that depart from Rome
Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Mediterranean Holiday Cruise : Florence, Mahon & PalmaStarting in Rome (Civitavecchia), Florence / Pisa (Livorno), Mahon, Menorca, Palma, Majorca, Barcelona
2026 Sails: Dec 22, More...
Deal link -> Special
17 Night - Mediterranean & Iberian Combination Cruise : Florence, Malaga & SevilleStarting in Rome (Civitavecchia), Florence / Pisa (Livorno), Mahon, Menorca, Palma, Majorca, Barcelona, Cartagena ES, Malaga, Casablanca, Tangier, Cadiz, Seville, Lisbon
2026 Sails: Dec 22, More...
7 Night - Amalfi Coast, Africa & IberiaStarting in Rome (Civitavecchia), Naples, Scenic Sailing Stromboli, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona
2026 Sails: Dec 23, More...
14 Night - Ancient Mediterranean AntiquitiesStarting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Dec 30, 2027: Feb 24, 2028: Feb 17, More...
7 Night - Journey to AntiquitiesStarting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2027 Sails: Jan 3, Feb 15, Dec 30, More...
10 Night - Invitation to IberiaStarting in Rome (Civitavecchia), Florence / Pisa / Tuscany (Livorno), Portofino, Nice, Provence (Marseille), Barcelona, Alicante, Granada (Motril), Seville (Cadiz), Lisbon
2027 Sails: Jan 4, More...
14 Night - Mediterranean & Adriatic OdysseyStarting in Rome (Civitavecchia), Naples, Sicily (Syracuse IT), Sail the Mediterranean Sea, Bari, Split, Zadar, Venice (Fusina), Ancona, Dubrovnik, Croatia, Corfu (Kerkyra), Kalamata, Crete (Souda Bay), Athens (Piraeus)
2027 Sails: Jan 5, More...
7 Night - Amalfi Coast, Africa & IberiaStarting in Rome (Civitavecchia), Salerno, Palermo, Sicily, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona
2027 Sails: Jan 5, Feb 16, Mar 2, Mar 16, Nov 13, Dec 12, 2028: Mar 16, More...
14 Night - Jewels of the MediterraneanStarting in Rome (Civitavecchia), Salerno, Palermo, Sicily, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona, Sete, Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia)
2027 Sails: Jan 5, Mar 2, Mar 16, More...
14 Night - Ancient Mediterranean AntiquitiesStarting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2027 Sails: Jan 6, More...
