Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

See all River Cruises that depart from Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

10 Night - Old World Exploration
Starting in Rome (Civitavecchia), Cruising the Tyrrhenian Sea, Valletta, La Goulette, Palermo (Sicily), Naples / Pompeii, Cruising the Tyrrhenian Sea, Tuscany (Livorno), Toulon, Palamos, Barcelona
2026 Sails: Nov 1, More...

Celebrity Cruises, Celebrity Constellation

15 Night - Spain & Morocco Transatlantic
Starting in Rome (Civitavecchia), Italy, Valencia, Spain, Cartagena ES, Malaga, Spain, Tangier, Morocco, Philipsburg, St Maarten, San Juan, Puerto Rico
2026 Sails: Nov 2, More...

Viking Ocean, Viking Vela

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Nov 3, 2028: Jan 11, More...

Viking Ocean, Viking Jupiter

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Nov 4, More...

Oceania Cruises, Oceania Sirena

7 Night - Ancient Sites & Cities
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Athens (Piraeus), Mitilini (Lesbos), Istanbul, Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Athens (Piraeus), Mitilini (Lesbos), Istanbul
2026 Sails: Nov 5, More...

Oceania Cruises, Oceania Allura

25 Night - Allura Autumn Crossing
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Valencia, Barcelona, Malaga, Agadir, Arrecife (Lanzarote), San Juan, Miami, Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Valencia, Barcelona, Malaga, Agadir, Arrecife (Lanzarote), San Juan, Miami
2026 Sails: Nov 7, More...

Oceania Cruises, Oceania Allura

10 Night - Artists & Aristocrats
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Valencia, Barcelona, Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Valencia, Barcelona
2026 Sails: Nov 7, More...

Viking Ocean, Viking Saturn

14 Night - Ancient Mediterranean Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Nov 7, More...

Viking Ocean, Viking Saturn

Regent Seven Seas, Seven Seas Grandeur

14 Night - New World Passage
Starting in Rome (Civitavecchia), Cruising the Mediterranean Sea, Palma De Mallorca, Cruising the Gibraltar Straight, Cruising the Atlantic Ocean, Funchal (Madeira), Cruising the Atlantic Ocean, Royal Naval Dockyard, Cruising the Atlantic Ocean, Miami
2026 Sails: Nov 8, More...

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