Rome Cruise Departures
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
7 Night - Jewels of the Italian and French Rivieras
Starting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome
2026 Sails: Aug 26, More...
7 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, 2027: May 13, May 20, May 27, Jun 3, Jun 10, Jun 17, Aug 26, Sep 2, Sep 9, Sep 16, Sep 23, Sep 30, Oct 7, Oct 14, Oct 21, More...
11 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise Tour
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Aug 27, More...7 Night - Enchanting Greece & the Amalfi Coast
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Aug 27, More...
11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Aug 31, Oct 12, More...
10 Night - Rome, Florence, Mykonos & More
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Catania, Sicily, Italy, Chania (Souda Bay), Crete, Greece, Santorini, Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Aug 31, More...10 Night - Vatican & Croatian Coastlines Cruise Tour
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Aug 31, More...12 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice, Venice, Italy, Cernobbio
2026 Sails: Sep 2, More...8 Night - Classic Italy & Dalmatian Coast
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Sep 2, More...
7 Night - Rome (Civitavecchia) / Venice
Starting in Rome (Civitavecchia), Gallipoli, Kotor, Korcula, Dubrovnik, Croatia, Zadar, Venice
2026 Sails: Sep 3, More...
Cruises that depart from Mediterranean: Italy: Rome
Cruises that visit Rome
Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Jewels of the Italian and French RivierasStarting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome
2026 Sails: Aug 26, More...
7 Night - Western Mediterranean CruiseStarting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, 2027: May 13, May 20, May 27, Jun 3, Jun 10, Jun 17, Aug 26, Sep 2, Sep 9, Sep 16, Sep 23, Sep 30, Oct 7, Oct 14, Oct 21, More...
11 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise TourStarting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Aug 27, More...
7 Night - Enchanting Greece & the Amalfi CoastStarting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Aug 27, More...
11 Night - Best of Italy & Croatia CruiseStarting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Aug 31, Oct 12, More...
10 Night - Rome, Florence, Mykonos & MoreStarting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Catania, Sicily, Italy, Chania (Souda Bay), Crete, Greece, Santorini, Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Aug 31, More...
10 Night - Vatican & Croatian Coastlines Cruise TourStarting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Aug 31, More...
12 Night - Lake Como & Adriatic Romance Cruise TourStarting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice, Venice, Italy, Cernobbio
2026 Sails: Sep 2, More...
8 Night - Classic Italy & Dalmatian CoastStarting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Sep 2, More...
7 Night - Rome (Civitavecchia) / VeniceStarting in Rome (Civitavecchia), Gallipoli, Kotor, Korcula, Dubrovnik, Croatia, Zadar, Venice
2026 Sails: Sep 3, More...
