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Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

See all River Cruises that depart from Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Oceania Cruises, Oceania Sirena
Oceania Sirena7 Night - Mediterranean Passage
Starting in Rome (Civitavecchia), Bastia (Corsica), Florence / Pisa / Tuscany (Livorno), Cinque Terre (La Spezia), Toulon, Palamos, Palma De Mallorca, Barcelona
2026 Sails: Dec 2, More...
Viking Ocean, Viking Mira
Viking Mira7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Dec 2, Dec 30, 2027: Feb 24, 2028: Feb 17, More...
Azamara Onward7 Night - Italy & Greece Cruise : Amalfi Coast, Siracusa & Olympia
Starting in Rome (Civitavecchia), Amalfi Coast (Salerno), Siracusa, Sicily, Olympia (Katakolon), Chania (Souda), Crete, Athens (Piraeus)
2026 Sails: Dec 5, More...
Azamara Cruises, Azamara Onward
Azamara Onward17 Night - Mediterranean & Egypt Combination Cruise : Salerno, Alexandria & Naples
Starting in Rome (Civitavecchia), Amalfi Coast (Salerno), Siracusa, Sicily, Olympia (Katakolon), Chania (Souda), Crete, Athens (Piraeus), Alexandria EG (Cairo), Egypt, Heraklion, (Crete), Valletta, Catania, (Sicily), Naples, Rome (Civitavecchia)
2026 Sails: Dec 5, More...
Viking Saturn7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 5, More...
Viking Ocean, Viking Vela
Viking Vela7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 7, More...
Viking Ocean, Viking Neptune
Viking Neptune14 Night - Ancient Mediterranean Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Dec 8, More...
Viking Ocean, Viking Neptune
Viking Neptune7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Dec 8, More...
Viking Ocean, Viking Libra
Viking Libra7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sail the Mediterranean Sea, Barcelona
2026 Sails: Dec 20, More...
Seven Seas Navigator14 Night - Spice Trail Sail
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Cruising the Mediterranean Sea, Alexandria EG, Cruising the Mediterranean Sea, Limassol, Rhodes, Heraklion (Crete), Kusadasi, Athens (Piraeus)
2026 Sails: Dec 21, More...

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Rome Cruise Departures