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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Windstar, Wind Surf
Wind Surf15 Night - Star Collector : Iconic Italy and Croatia
Starting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Aug 26, More...
Windstar, Wind Surf
Wind Surf7 Night - Jewels of the Italian and French Rivieras
Starting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome
2026 Sails: Aug 26, More...
Atlas Ocean Voyages, World Traveller
World Traveller8 Night - Athens to Catania
Starting in Piraeus (Athens), Bodrum, Patmos, Skiathos, Ermoupolis (Syros), Hydra, Greece, Zakynthos, Catania (Sicily)
2026 Sails: Aug 27, More...
Atlas Ocean Voyages, World Traveller
World Traveller13 Night - Athens to Rome
Starting in Piraeus (Athens), Bodrum, Patmos, Skiathos, Ermoupolis (Syros), Hydra, Greece, Zakynthos, Catania (Sicily), Amalfi (Ravello), Italy, Porto Cervo (Sardinia), Bonifacio (Corsica), Civitavecchia (Rome)
2026 Sails: Aug 27, More...
Norwegian Line Tours, Norwegian Gem Tours
Norwegian Gem Tours10 Night - Pre Venice Cruisetour
Starting in At Hotel, Venice (Ravenna), Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Aug 27, Oct 22, More...
Oceania Cruises, Oceania Sirena
Oceania Sirena14 Night - Mediterranean Mosaic
Starting in Istanbul, Izmir, Santorini, Rhodes, Heraklion (Crete), Dubrovnik, Croatia, Kotor, Sarande, Katakolon, Taormina (Sicily), Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Aug 27, More...
PONANT, Le Bougainville
Le Bougainville9 Night - From the Adriatic to the Ionian Sea
Starting in Dubrovnik, Croatia, Korcula, Mljet, Komiza, Vis Island, Vis Island, Kotor, Parga, Gallipoli, Taormina, Sicily, Valletta
2026 Sails: Aug 27, More...
Royal Caribbean, Legend of the Seas
Legend of the Seas7 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, More...
Uniworld Tours, S.S. La Venezia Tours
S.S. La Venezia Tours13 Night - Grand Highlights of Italy & Slovenia
Starting in Ljubljana, Ljubljana (Lake Bled), Ljubljana (Postojna), Transfer to Venice, Venice, Venice (Padua), Mazzorbo (Burano), Mazzorbo, Burano, Chioggia, Chioggia, Chioggia, Venice, Venice, Venice, Transfer to Rome, Rome
2026 Sails: Aug 27, Sep 17, Sep 24, Oct 22, Oct 29, More...
Windstar, Wind Spirit
Wind Spirit7 Night - Enchanting Greece & the Amalfi Coast
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Aug 27, More...

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Mediterranean Cruise Departures