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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Royal Caribbean, Brilliance of the Seas
Brilliance of the Seas7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Catania, Sicily, Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Aug 17, More...
Sea Cloud, Sea Cloud II
Sea Cloud II8 Night - On the Trail of the Old Venetians
Starting in Venice, Komiza / Vis Island, Hvar, Korcula, Trogir, Sibenik, Rovinj, Venice
2026 Sails: Aug 17, More...
Viking River Tours, Viking Amun Tours
Viking Amun Tours11 Night - Pharaohs & Pyramids
Starting in Cairo, Luxor, Qena, Luxor, Esna, Aswan, Kom Ombo, Edfu, Luxor, Cairo
2026 Sails: Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, Oct 12, Oct 19, Oct 26, Nov 2, Nov 9, Nov 23, Nov 30, Dec 7, Dec 14, Dec 21, Dec 28, 2027: Jan 4, Jan 11, Jan 18, Jan 25, Feb 1, More...
MSC Cruises, MSC Fantasia
MSC Fantasia9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Santorini, Greece, Piraeus (Athens), Greece, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Aug 18, More...
Viking Ocean, Viking Sea
Viking Sea7 Night - Ancient Mediterranean Treasures
Starting in Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Aug 18, More...
Viking Ocean, Viking Vesta
Viking Vesta7 Night - Ancient Mediterranean Treasures
Starting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus)
2026 Sails: Aug 18, More...
Viking River Tours, Viking Sobek Tours
Viking Sobek Tours11 Night - Pharaohs & Pyramids
Starting in Cairo, Luxor, Qena, Luxor, Esna, Aswan, Kom Ombo, Edfu, Luxor, Cairo
2026 Sails: Aug 18, Aug 25, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, Oct 20, Oct 27, Nov 3, Nov 10, Nov 17, Nov 24, Dec 1, Dec 8, Dec 15, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Jan 19, Jan 26, Feb 2, Feb 9, More...
Windstar, Wind Surf
Wind Surf15 Night - Star Collector : Iconic Italy and Croatia
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome
2026 Sails: Aug 18, More...
MSC Cruises, MSC Fantasia
MSC Fantasia9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Santorini, Greece, Piraeus (Athens), Greece, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: Aug 19, More...
SeaDream Yacht Club, SeaDream I
SeaDream I10 Night - Greece & Italian Discovery Cruise
Starting in Athens (Piraeus), Hydra, Corinth Canal Transit, Itea (Delphi), Sailing the Ionian Sea, Taormina (Mount Etna) Sicily, Lipari, Aeolian Islands, Capri, Amalfi, Positano, Ponza, Rome (Civitavecchia)
2026 Sails: Aug 19, More...

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Mediterranean Cruise Departures