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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Royal Caribbean, Brilliance of the Seas
Brilliance of the Seas7 Night - Best of Greece Cruise
Starting in Athens (Piraeus), Greece, Mykonos, Greece, Ephesus (Kusadasi), Turkey, Santorini, Greece, Chania (Souda), Crete, Greece, Olympia (Katakolon), Greece, Rome (Civitavecchia), Italy
2026 Sails: Jul 20, Aug 31, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean Roundtrip from Cagliari
Starting in Cagliari, Italy, Naples, Italy, Bahia De Capri, Civitavecchia / Rome, Genoa / Portofino, Bahia Del Parque Nacional De Las Calanques, Marseille, France, Barcelona, Spain, El punto mas oscuro del mar de las, Balearic Islands, Cagliari, Italy
2026 Sails: Jul 21, More...
Oceania Cruises, Oceania Allura
Oceania Allura7 Night - Legendary Turkey & Greece
Starting in Istanbul, Bozcaada (Troy), Mitilini (Lesbos), Izmir, Chios, Kos, Santorini, Athens (Piraeus)
2026 Sails: Jul 21, More...
Silversea, Silver Muse
Silver Muse10 Night - Fusina to Civitavecchia
Starting in Fusina (Venice), Zadar, Split, Dubrovnik, Croatia, Bari, Kotor, Giardini Naxos (Sicily), Palermo, Sicily, Naples, Civitavecchia (Rome)
2026 Sails: Jul 21, More...
Viking Ocean, Viking Sea
Viking Sea7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Jul 21, Oct 16, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Europe Roundtrip from Naples
Starting in Naples, Italy, Bahia De Capri, Civitavecchia / Rome, Genoa / Portofino, Bahia Del Parque Nacional De Las Calanques, Marseille, France, Barcelona, Spain, El punto mas oscuro del mar de las, Balearic Islands, Cagliari, Italy, Naples, Italy
2026 Sails: Jul 22, More...
MSC Cruises, MSC Fantasia
MSC Fantasia9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Jul 22, Sep 23, More...
Norwegian Cruise Line, Norwegian Viva
Norwegian Viva9 Night - Greek Isles & Italy
Starting in Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Valletta, Malta, Santorini Island, Greece, Piraeus / Athens, Greece, Kusadasi, Turkey, Istanbul, Turkey
2026 Sails: Jul 22, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Cagliari, Napoli, Civitavecchia (Rome)
2026 Sails: Jul 23, Jul 30, Aug 6, More...
MSC Cruises, MSC Fantasia
MSC Fantasia9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: Jul 23, Sep 24, More...

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Mediterranean Cruise Departures