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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Silversea, Silver Nova
Silver Nova7 Night - Athens to Athens
Starting in Athens (Piraeus), Nafplion, Milos, Heraklion, Rhodes, Kusadasi, Mykonos, Athens (Piraeus)
2026 Sails: Jul 19, Aug 9, Aug 23, More...
Silversea, Silver Shadow
Silver Shadow6 Night - Valletta to Nice
Starting in Valletta, Giardini Naxos (Sicily), Salerno, Gaeta, Portoferraio (Elba), Portofino, Nice
2026 Sails: Jul 19, Jul 31, Aug 24, More...
Atlas Ocean Voyages, World Traveller
World Traveller10 Night - Athens to Rome
Starting in Piraeus (Athens), Santorini, Folegandros, Skiathos, Mykonos, Messina (Sicily), Amalfi (Ravello), Italy, Isola di Ponza, Italy, Civitavecchia (Rome)
2026 Sails: Jul 20, More...
Celebrity Cruises, Celebrity Constellation
Celebrity Constellation11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Dubrovnik, Croatia, Montenegro, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Jul 20, Sep 21, More...
Cunard Line, Queen Victoria
Queen Victoria7 Night - Italy, France and Spain
Starting in Civitavecchia (tours to Rome), Italy, Livorno (tours to Florence or Pisa), Italy, La Seyne-sur-Mer (for Toulon), France, Calvi, Corsica, France, Valencia, Spain, Barcelona, Spain
2026 Sails: Jul 20, More...
Cunard Line, Queen Victoria
Queen Victoria14 Night - Adriatic and Western Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, Livorno (tours to Florence or Pisa), Italy, La Seyne-sur-Mer (for Toulon), France, Calvi, Corsica, France, Valencia, Spain, Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy
2026 Sails: Jul 20, More...
Emerald Cruises, Emerald Sakara
Emerald Sakara10 Night - Mediterranean Delights
Starting in Valletta, Malta, Mgarr, Malta, Porto Empedocle, Italy, Mazara del Vallo, Italy, La Goulette (Tunis), Tunisia, Trapani, Italy, Palermo, Italy, Lipari, Italy, Giardini Naxos, Italy, Syracuse IT, Italy, Valletta, Malta
2026 Sails: Jul 20, More...
EXPLORA II7 Night - A Journey to Adriatic Wonders & Whispered Ancient Secrets
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Kotor, Milos, Piraeus (Athens)
2026 Sails: Jul 20, Sep 21, Oct 12, More...
EXPLORA II14 Night - An Extended Journey of Sunlit Shores & Quiet Seas
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Kotor, Milos, Piraeus (Athens), Bari, Nydri, Lefkada, Pylos, Katapola, Mykonos, Piraeus (Athens)
2026 Sails: Jul 20, Sep 21, More...
Regent Seven Seas, Seven Seas Splendor
Seven Seas Splendor8 Night - History & Romance
Starting in Venice (Trieste), Rijeka, Zadar, Dubrovnik, Croatia, Bari, Kotor, Igoumenitsa, Cruising the Mediterranean Sea, Athens (Piraeus)
2026 Sails: Jul 20, More...

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Mediterranean Cruise Departures