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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

MSC Cruises, MSC Splendida
MSC Splendida7 Night - Mediterranean
Starting in La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta
2026 Sails: Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, More...
Norwegian Cruise Line, Norwegian Viva
Norwegian Viva10 Night - Greek Isles & Italy
Starting in Venice (Ravenna), Italy, Dubrovnik, Croatia, Montenegro, Piraeus / Athens, Greece, Kusadasi, Turkey, Rhodes, Greece, Santorini Island, Greece, Istanbul, Turkey
2026 Sails: Jul 3, More...
Sea Cloud, Sea Cloud II
Sea Cloud II7 Night - Sailing Paradise Since Homer's Time
Starting in Piraeus, Spetses / Saronic Islands, Nafplion / Peloponnese, Milos / Cyclades, Patmos / Dodecanese, Kusadasi, Istanbul
2026 Sails: Jul 3, More...
Silversea, Silver Muse
Silver Muse9 Night - Fusina to Fusina
Starting in Fusina (Venice), Trieste, Rovinj, Kotor, Bari, Dubrovnik, Croatia, Hvar, Zadar, Fusina (Venice)
2026 Sails: Jul 3, More...
AmaWaterways Tours, AmaSerena Tours
AmaSerena Tours10 Night - Swiss Alps & Rhine Castles with Lake Como Pre-Cruise
Starting in Laconia, Lucerne, Basel, Strasbourg, Ludwigshafen, Lahnstein, Cologne, Amsterdam
2026 Sails: Jul 4, Jul 18, Aug 1, Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...
Celebrity Cruises, Celebrity Infinity
Celebrity Infinity7 Night - Best of Greece Cruise
Starting in Athens (Piraeus), Greece, Rhodes, Greece, Ephesus (Kusadasi), Turkey, Santorini, Greece, Hydra, Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jul 4, Aug 1, More...
Celestyal Cruises, Celestyal Discovery
Celestyal Discovery3 Night - Iconic Greek Islands
Starting in Kusadasi, Patmos, Heraklion, Santorini, Lavrion, Athens, Mykonos, Kusadasi
2026 Sails: Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, 2027: Apr 3, Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Zakynthos, Argostoli (Cephalonia), Dubrovnik, Croatia, Split, Marghera (Venice)
2026 Sails: Jul 4, Aug 1, Aug 15, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa7 Night - Eastern Mediterranean from Catania
Starting in Catania, Taranto, Argostoli (Cephalonia), Mykonos, Piraeus (Athens), Malta / La Valletta, Catania
2026 Sails: Jul 4, Jul 18, Aug 1, Aug 8, Aug 15, Aug 29, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome)
2026 Sails: Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, More...

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Mediterranean Cruise Departures