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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Jul 4, Sep 26, More...
Emerald Cruises, Emerald Kaia
Emerald Kaia7 Night - Adriatic Discovery : Venice, Istria & the Croatian Archipelago
Starting in Venice, Italy, Piran, Slovenia, Mali Losinj, Croatia, Senj, Croatia / Baska, Krk Island, Croatia, Opatija, Croatia, Rovinj, Croatia, Venice, Italy
2026 Sails: Jul 4, Jul 25, 2027: Jun 5, More...
Emerald Cruises, Emerald Kaia
Emerald Kaia14 Night - Discover the Gems of Italy & Croatia
Starting in Venice, Italy, Piran, Slovenia, Mali Losinj, Croatia, Senj, Croatia / Baska, Krk Island, Croatia, Opatija, Croatia, Rovinj, Croatia, Venice, Italy, Rovinj, Croatia, Sibenik, Croatia, Trogir, Croatia, Vis / Hvar, Croatia, Hvar, Croatia, Korcula, Croatia, Dubrovnik, Croatia
2026 Sails: Jul 4, Jul 25, More...
Emerald Cruises, Emerald Sakara
Emerald Sakara7 Night - Enchanting Italian Coastlines
Starting in Civitavecchia (Rome), Italy, Amalfi, Italy / Capri, Italy, Capri, Italy / Sorrento, Italy, Sorrento, Italy, Gaeta, Italy, Porto Cervo, Italy, Bonifacio, France, Civitavecchia (Rome), Italy
2026 Sails: Jul 4, Aug 8, 2027: Aug 28, More...
MSC Cruises, MSC Armonia
MSC Armonia7 Night - Mediterranean
Starting in Split, Croatia, Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy, Split, Croatia
2026 Sails: Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Oct 3, Oct 10, Oct 17, Oct 24, 2027: May 1, May 8, May 15, May 22, Jun 5, Jun 12, Jun 26, Jul 3, More...
MSC Cruises, MSC Fantasia
MSC Fantasia9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Jul 4, Jul 13, Jul 31, Aug 9, Aug 27, Sep 5, Sep 14, Oct 2, Oct 11, Oct 20, Oct 29, Nov 7, More...
Princess Cruises, Sun Princess
Sun Princess7 Night - Mediterranean with Italy & Turkey
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jul 4, Jul 25, Aug 15, Sep 5, Sep 26, Oct 17, More...
Ritz-Carlton, Ilma
Ilma7 Night - Athens (Piraeus) / Athens (Lavrion)
Starting in Athens (Piraeus), Amorgos, Rhodes, Bodrum, Patmos, Santorini, Milos, Athens (Lavrion)
2026 Sails: Jul 4, More...
Royal Caribbean, Explorer of the Seas
Explorer of the Seas7 Night - Greek Isles Cruise
Starting in Ravenna, Italy, Santorini, Greece, Mykonos, Greece, Athens (Piraeus), Greece, Argostoli, Greece, Ravenna, Italy
2026 Sails: Jul 4, Sep 26, More...
Royal Caribbean, Legend of the Seas
Legend of the Seas7 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Provence (Marseille), France, Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Jul 4, More...

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Mediterranean Cruise Departures