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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

MSC Cruises, MSC Splendida
MSC Splendida7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy
2026 Sails: Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 24, Oct 1, Oct 8, Oct 15, Oct 22, Oct 29, Nov 5, More...
Oceania Cruises, Oceania Nautica
Oceania Nautica10 Night - Mediterranean Medley
Starting in Rome (Civitavecchia), Salerno, Taormina (Sicily), Valletta, Ibiza, Valencia, Barcelona, Provence (Marseille), Cannes, Monte Carlo
2026 Sails: Jul 2, More...
PONANT, Le Boreal
Le Boreal8 Night - Antique Wonders of the Aegean
Starting in Istanbul, Bozcaada, Sailing in the Dardanelles, Patmos, Symi, Amorgos, Sailing in the Santorini Caldera, Paros, Adamas, Milos, Hydra, Athens
2026 Sails: Jul 2, More...
Riviera River, MV Felicita
MV Felicita7 Night - Dubrovnik, Split and Jewels of the Dalmatian Coast Yacht Cruise
Starting in Dubrovnik, Croatia
2026 Sails: Jul 2, Jul 16, Jul 23, Jul 30, Aug 6, Aug 27, Oct 1, 2027: May 13, May 20, May 27, Jun 3, Jun 10, Jun 24, Jul 1, Jul 8, Jul 22, Jul 29, Aug 12, Aug 19, Sep 2, Sep 16, Sep 23, Sep 30, More...
Star Clippers, Star Clipper
Star Clipper11 Night - Italy, Montenegro, Croatia
Starting in Venice, Italy, Mali Losinj, Croatia, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Otranto, Italy, Taormina, Sicily, Italy, Lipari / Aeolian Islands, Italy, Amalfi, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: Jul 2, Aug 20, More...
Viking Ocean, Viking Star
Viking Star9 Night - Empires of the Mediterranean
Starting in Venice (Chioggia), Koper, Zadar, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Santorini (Thira), Athens (Piraeus)
2026 Sails: Jul 2, More...
Windstar, Wind Spirit
Wind Spirit7 Night - Enchanting Greece & the Amalfi Coast
Starting in Athens, Greece, Monemvasia, Gythion, Messina (Taormina), Sorrento, Rome
2026 Sails: Jul 2, Oct 15, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Eastern Mediterranean from Athens (Pireo)
Starting in Piraeus (Athens), Istanbul, Mykonos, Heraklion (Crete), Rhodes, Thira (Santorini), Piraeus (Athens)
2026 Sails: Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome)
2026 Sails: Jul 3, Sep 25, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Jul 3, More...

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Mediterranean Cruise Departures