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Lake Como Cruise Departures

Cruises that depart from Mediterranean: Italy: Lake Como

Cruises that visit Lake Como

See all River Cruises that depart from Lake Como

Click on a cruise ship itinerary sailing from Lake Como (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Lake Como), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Wind Spirit Tours14 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Royal Victoria Varenna Lake Como Hotel or Similar, Cernobbio, Royal Victoria Varenna Lake Como Hotel or Similar, Venice, Hilton Molino Stucky or Similar, Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Otranto, Messina, Taormina, Vibo Valentia / Marina Velentia, Sorrento, Civitavecchia, Rome
2028 Sails: May 14, More...
Avalon Imagery II Tours14 Night - The Rhine & Moselle W / Lake Como Lucerne -Nb
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Strasbourg, France, Ludwigshafen, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Bernkastel, Trier / Excursion to Luxembourg, Cochem, Cologne, Amsterdam, the Netherlands, Amsterdam (Disembarkation)
2028 Sails: May 19, Jun 21, Jul 11, Jul 30, More...
Wind Spirit Tours12 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Royal Victoria Varenna Lake Como Hotel or Similar, Cernobbio, Royal Victoria Varenna Lake Como Hotel or Similar, Venice, Hilton Molino Stucky or Similar, Venice, Rovinj, Split, Dubrovnik, Croatia, Korcula, Messina, Taormina, Sorrento, Civitavecchia, Rome
2028 Sails: Jul 19, More...
Avalon Visionary Tours14 Night - The Rhine & Moselle W / Lake Como Lucerne -Nb
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Strasbourg, France, Ludwigshafen, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Bernkastel, Trier / Excursion to Luxembourg, Cochem, Cologne, Amsterdam, the Netherlands, Amsterdam (Disembarkation)
2028 Sails: Sep 8, More...
Wind Spirit Tours13 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Royal Victoria Varenna Lake Como Hotel or Similar, Cernobbio, Royal Victoria Varenna Lake Como Hotel or Similar, Venice, Hilton Molino Stucky or Similar, Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Otranto, Messina, Taormina, Sorrento, Civitavecchia, Rome
2028 Sails: Oct 12, More...
Avalon Panorama Tours11 Night - Christmastime On the Romantic Rhine with in Lake Como, in Lucerne with Swiss Alps (Northbound)
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Ludwigshafen / Heidelberg Excursion, Rudesheim / Rhine Gorge, Cologne, Germany, Mainz, Frankfurt (Disembarkation)
2028 Sails: Dec 5, More...
Avalon Vista Tours11 Night - Christmastime On the Romantic Rhine with in Lake Como, in Lucerne with Swiss Alps (Northbound)
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Ludwigshafen / Heidelberg Excursion, Rudesheim / Rhine Gorge, Cologne, Germany, Mainz, Frankfurt (Disembarkation)
2028 Sails: Dec 12, More...


Lake Como Cruise Departures