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Colon Cruise Departures

Cruises that depart from Central America: Panama: Colon

Cruises that visit Colon

Click on a cruise ship itinerary sailing from Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Colon
Shore Excursions

PONANT, Le Laperouse
Le Laperouse7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2027 Sails: Feb 26, More...
PONANT, Le Laperouse
Le Laperouse10 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, San Blas Islands, Cartagena, Santa Marta, Bonaire, Tobago Cays, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2027 Sails: Mar 12, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Kralendijk, Bonaire, Oranjestad, Aruba, Colon, Panama
2027 Sails: Mar 13, Mar 27, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit13 Night - Central America from Colon to Cozumel
Starting in Colon, San Blas Islands, Bocas del Toro, Puerto Limon, Isla Guanaja, French Key, Belize City, Lighthouse Reef / Half Moon Caye, Cozumel, Mexico
2027 Sails: Mar 13, More...
PONANT, Le Bellot
Le Bellot10 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2027 Sails: Apr 8, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Willemstad AN, Curacao, Colon, Panama
2027 Sails: Apr 10, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Colon to San Juan Cruise
Starting in Colon, Panama, Kingstown, St Vincent, Castries, St Lucia, St Johns AG, Antigua, Tortola, San Juan, Puerto Rico
2027 Sails: Apr 24, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2027 Sails: Dec 4, Dec 11, Dec 25, 2028: Jan 29, Feb 5, Feb 12, Mar 11, Mar 25, Apr 22, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Dec 18, 2028: Jan 15, Feb 19, Apr 15, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2028 Sails: Jan 1, Jan 22, Feb 26, Mar 4, Apr 8, More...

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Colon Cruise Departures