Ohio River Cruises
River Cruises sailing on the Ohio River
River cruises by river name
Cruises on the Ohio River also sail:
Cumberland River : Lake Barkley : Licking River : Mississippi River : Tennessee River
8 Night - Music Cities Cruise
Starting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 23, Aug 4, Oct 27, 2027: Oct 29, More...
8 Night - Ohio River Cruise
Starting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 2, Jul 17, Jul 31, Aug 14, More...
8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, More...8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, More...8 Night - Ohio River Cruise
Starting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 10, Jul 24, More...
21 Night - Mississippi River Odyssey
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois, Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Jul 18, More...14 Night - The Big Easy to the Gateway City
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jul 18, More...
8 Night - Tennessee Rivers Cruise
Starting in Nashville, TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Savannah, TN, Florence, AL, Decatur, AL, Cruising the Tennessee River, Chattanooga, TN
2026 Sails: Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, 2027: Jul 27, Aug 10, Aug 24, Sep 7, 2028: Jul 25, Aug 8, Aug 22, Sep 5, Sep 19, Oct 3, More...15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...8 Night - Tennessee Rivers Cruise
Starting in Chattanooga, TN, Cruising the Tennessee River, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, 2027: Aug 3, Aug 17, Aug 31, Sep 14, 2028: Aug 1, Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...
River Cruises sailing on the Ohio River
Click on a cruise ship itinerary sailing on the Ohio River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Ohio River), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the Ohio River also sail:
Cumberland River : Lake Barkley : Licking River : Mississippi River : Tennessee River
8 Night - Music Cities CruiseStarting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 23, Aug 4, Oct 27, 2027: Oct 29, More...
8 Night - Ohio River CruiseStarting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 2, Jul 17, Jul 31, Aug 14, More...
8 Night - Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, More...
8 Night - Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, More...
8 Night - Ohio River CruiseStarting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 10, Jul 24, More...
21 Night - Mississippi River OdysseyStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois, Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Jul 18, More...
14 Night - The Big Easy to the Gateway CityStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jul 18, More...
8 Night - Tennessee Rivers CruiseStarting in Nashville, TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Savannah, TN, Florence, AL, Decatur, AL, Cruising the Tennessee River, Chattanooga, TN
2026 Sails: Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, 2027: Jul 27, Aug 10, Aug 24, Sep 7, 2028: Jul 25, Aug 8, Aug 22, Sep 5, Sep 19, Oct 3, More...
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...
8 Night - Tennessee Rivers CruiseStarting in Chattanooga, TN, Cruising the Tennessee River, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, 2027: Aug 3, Aug 17, Aug 31, Sep 14, 2028: Aug 1, Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...
