Ohio River Cruises
River Cruises sailing on the Ohio River
River cruises by river name
Cruises on the Ohio River also sail:
Cumberland River : Lake Barkley : Licking River : Mississippi River : Tennessee River
11 Night - Smoky Mountains National Park
Starting in Nashville, TN, Afternoon of Cruising, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Savannah, TN, Florence, AL, Decatur, AL, Chattanooga, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Knoxville, TN
2026 Sails: Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, More...11 Night - Smoky Mountains National Park
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...
15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...
7 Night - Nashville, Memphis & the Cumberland
Starting in Memphis, Tennessee, Scenic Sailing Upper Mississippi, Cape Girardeau, Missouri, Paducah, Kentucky, Clarksville, Tennessee, Nashville, Tennessee
2026 Sails: Oct 27, Nov 10, More...7 Night - Nashville, Memphis & the Cumberland
Starting in Nashville, Tennessee, Clarksville, Tennessee, Paducah, Kentucky, Cape Girardeau, Missouri, Scenic Sailing Upper Mississippi, Memphis, Tennessee
2026 Sails: Nov 3, More...7 Night - Nashville, Memphis & the Cumberland
Starting in Nashville, Tennessee, Clarksville, Tennessee, Paducah, Kentucky, Cape Girardeau, Missouri, Scenic Sailing Upper Mississippi, Memphis, Tennessee
2026 Sails: Nov 17, More...14 Night - Bayous, Blues & Bluegrass
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Lower Mississippi, Paducah, Kentucky, Henderson, Kentucky, Owensboro, Kentucky, Louisville, Kentucky
2027 Sails: Jun 1, Oct 26, More...7 Night - Mississippi & Ohio River Explorer
Starting in Memphis, Tennessee, Scenic Sailing Lower Mississippi, Paducah, Kentucky, Henderson, Kentucky, Owensboro, Kentucky, Louisville, Kentucky
2027 Sails: Jun 8, Nov 2, More...14 Night - Bayous, Blues & Bluegrass
Starting in Louisville, Kentucky, Owensboro, Kentucky, Henderson, Kentucky, Paducah, Kentucky, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Lower Mississippi, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, St Francisville, Louisiana, Baton Rouge, Louisiana, Darrow, Louisiana, New Orleans, Louisiana
2027 Sails: Jun 15, Nov 9, More...7 Night - Mississippi & Ohio River Explorer
Starting in Louisville, Kentucky, Owensboro, Kentucky, Henderson, Kentucky, Paducah, Kentucky, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2027 Sails: Jun 15, Nov 9, More...
River Cruises sailing on the Ohio River
Click on a cruise ship itinerary sailing on the Ohio River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Ohio River), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the Ohio River also sail:
Cumberland River : Lake Barkley : Licking River : Mississippi River : Tennessee River
11 Night - Smoky Mountains National ParkStarting in Nashville, TN, Afternoon of Cruising, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Savannah, TN, Florence, AL, Decatur, AL, Chattanooga, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Knoxville, TN
2026 Sails: Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, More...
11 Night - Smoky Mountains National ParkStarting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...
7 Night - Nashville, Memphis & the CumberlandStarting in Memphis, Tennessee, Scenic Sailing Upper Mississippi, Cape Girardeau, Missouri, Paducah, Kentucky, Clarksville, Tennessee, Nashville, Tennessee
2026 Sails: Oct 27, Nov 10, More...
7 Night - Nashville, Memphis & the CumberlandStarting in Nashville, Tennessee, Clarksville, Tennessee, Paducah, Kentucky, Cape Girardeau, Missouri, Scenic Sailing Upper Mississippi, Memphis, Tennessee
2026 Sails: Nov 3, More...
7 Night - Nashville, Memphis & the CumberlandStarting in Nashville, Tennessee, Clarksville, Tennessee, Paducah, Kentucky, Cape Girardeau, Missouri, Scenic Sailing Upper Mississippi, Memphis, Tennessee
2026 Sails: Nov 17, More...
14 Night - Bayous, Blues & BluegrassStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Lower Mississippi, Paducah, Kentucky, Henderson, Kentucky, Owensboro, Kentucky, Louisville, Kentucky
2027 Sails: Jun 1, Oct 26, More...
7 Night - Mississippi & Ohio River ExplorerStarting in Memphis, Tennessee, Scenic Sailing Lower Mississippi, Paducah, Kentucky, Henderson, Kentucky, Owensboro, Kentucky, Louisville, Kentucky
2027 Sails: Jun 8, Nov 2, More...
14 Night - Bayous, Blues & BluegrassStarting in Louisville, Kentucky, Owensboro, Kentucky, Henderson, Kentucky, Paducah, Kentucky, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Lower Mississippi, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, St Francisville, Louisiana, Baton Rouge, Louisiana, Darrow, Louisiana, New Orleans, Louisiana
2027 Sails: Jun 15, Nov 9, More...
7 Night - Mississippi & Ohio River ExplorerStarting in Louisville, Kentucky, Owensboro, Kentucky, Henderson, Kentucky, Paducah, Kentucky, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2027 Sails: Jun 15, Nov 9, More...
