Louisville River Cruises

River Cruises that visit North America: United States: Kentucky: Louisville

River Cruises that depart from Louisville

See all Cruises that visit Louisville

Ohio River Cruises

Click on a cruise ship itinerary that visits Louisville (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Louisville), please visit: Cruise Search or try our Virtual Cruise Advisor™.

15 Night - Grand Ohio River Cruise
Starting in St Louis, MO, Cruising the Mississippi River, Paducah, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Louisville, KY, Madison, IN, Cincinnati, OH, Day of Cruising, Maysville, KY, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jun 19, 2027: Jun 18, 2028: Jul 1, More...

American Cruise Lines, American Heritage

11 Night - Mississippi River Gateway Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA / Houmas House, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, 2027: Jun 29, 2028: Jun 28, More...

American Cruise Lines, American Melody

8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, 2027: Jul 2, Jul 16, Jul 30, 2028: Jul 15, Jul 29, More...

American Cruise Lines, American Heritage

8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, 2027: Jul 16, Jul 30, Aug 13, 2028: Jul 15, Jul 29, Aug 12, More...

American Cruise Lines, American Melody

15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Aug 13, 2028: Aug 12, More...

American Cruise Lines, American Heritage

15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, 2027: Aug 27, 2028: Aug 26, More...

American Cruise Lines, American Symphony