Charleston River Cruise Departures

River Cruises that depart from North America: United States: South Carolina: Charleston

River Cruises that visit Charleston

See all Cruises that depart from Charleston

Click on a cruise ship itinerary sailing from Charleston (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Charleston), please visit: Cruise Search or try our Virtual Cruise Advisor™.

8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2025 Sails: Nov 21, Dec 5, Dec 19, 2026: Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, Nov 16, Nov 30, Dec 14, Dec 28, 2027: Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, More...

American Cruise Lines, American Eagle

8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Mar 25, Apr 8, Apr 22, May 6, 2027: Mar 26, Apr 9, Apr 23, May 7, 2028: Jan 29, Feb 12, Feb 26, Mar 11, Mar 25, Apr 8, Apr 22, May 6, More...

American Cruise Lines, American Legend

8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2027 Sails: Feb 3, Feb 17, Mar 3, Mar 17, Nov 29, Dec 13, Dec 27, 2028: Feb 17, Mar 2, More...

Charleston River Cruise Departures