San Diego Cruises
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
22 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...
33 Night - Grand World Voyage
Starting in Yokohama (Tokyo), Japan, Hakodate, Japan, Cross International Dateline, Kodiak, Alaska, Sitka, Alaska, Ketchikan, Alaska, Seattle, Washington, San Diego, California, Manzanillo, Mexico, Puerto Chiapas, Mexico, Acajutla, El Salvador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Apr 14, More...
30 Night - Alaska & North Pacific Crossing
Starting in Tokyo (Yokohama), Japan, Miyako, Japan, Aomori, Japan, Hakodate, Japan, Cross International Date Line, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Sitka, Alaska, Ketchikan, Alaska, Victoria CA, Vancouver, Canada, Seattle, Washington, Astoria, Oregon, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California
2026 Sails: Apr 16, More...
18 Night - Baja Peninsula, Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 18, More...14 Night - Mexican Riviera & Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 18, More...
7 Night - Classic California Coast
Starting in San Francisco, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California, San Francisco, California
2026 Sails: Apr 19, More...
18 Night - Msc Grand Voyages
Starting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...11 Night - Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 25, More...
7 Night - Pacific Wine Country
Starting in Los Angeles, California, San Diego, California, Santa Barbara, California, Astoria, Oregon, Victoria CA, Vancouver, Canada
2026 Sails: Apr 25, More...
8 Night - Pacific Coastal Cruise
Starting in Los Angeles, California, San Diego, California, San Francisco, California, Victoria CA, Canada, Vancouver, British Columbia
2026 Sails: Apr 30, More...
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
Click on a cruise ship itinerary that visits San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.
22 Night - Panama CanalStarting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...
33 Night - Grand World VoyageStarting in Yokohama (Tokyo), Japan, Hakodate, Japan, Cross International Dateline, Kodiak, Alaska, Sitka, Alaska, Ketchikan, Alaska, Seattle, Washington, San Diego, California, Manzanillo, Mexico, Puerto Chiapas, Mexico, Acajutla, El Salvador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Apr 14, More...
30 Night - Alaska & North Pacific CrossingStarting in Tokyo (Yokohama), Japan, Miyako, Japan, Aomori, Japan, Hakodate, Japan, Cross International Date Line, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Sitka, Alaska, Ketchikan, Alaska, Victoria CA, Vancouver, Canada, Seattle, Washington, Astoria, Oregon, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California
2026 Sails: Apr 16, More...
18 Night - Baja Peninsula, Mexican Riviera & Pacific CoastStarting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 18, More...
14 Night - Mexican Riviera & Baja PeninsulaStarting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 18, More...
7 Night - Classic California CoastStarting in San Francisco, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California, San Francisco, California
2026 Sails: Apr 19, More...
18 Night - Msc Grand VoyagesStarting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...
11 Night - Mexican Riviera & Pacific CoastStarting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 25, More...
7 Night - Pacific Wine CountryStarting in Los Angeles, California, San Diego, California, Santa Barbara, California, Astoria, Oregon, Victoria CA, Vancouver, Canada
2026 Sails: Apr 25, More...
8 Night - Pacific Coastal CruiseStarting in Los Angeles, California, San Diego, California, San Francisco, California, Victoria CA, Canada, Vancouver, British Columbia
2026 Sails: Apr 30, More...
