San Diego Cruises
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
7 Night - Classic California Coast
Starting in San Francisco, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California, San Francisco, California
2026 Sails: Apr 19, More...
18 Night - Msc Grand Voyages
Starting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...
11 Night - Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 25, More...
7 Night - Pacific Wine Country
Starting in Los Angeles, California, San Diego, California, Santa Barbara, California, Astoria, Oregon, Victoria CA, Vancouver, Canada
2026 Sails: Apr 25, More...
8 Night - Pacific Coastal Cruise
Starting in Los Angeles, California, San Diego, California, San Francisco, California, Victoria CA, Canada, Vancouver, British Columbia
2026 Sails: Apr 30, More...
7 Night - Pacific Wine Country
Starting in Los Angeles, California, San Diego, California, San Francisco, California, Astoria, Oregon, Victoria CA, Vancouver, Canada
2026 Sails: May 6, More...
9 Night - Wine Country Coastal
Starting in Vancouver, Canada, Seattle, Washington, Astoria, Oregon, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California
2026 Sails: May 7, More...
20 Night - Seattle to Miami
Starting in Seattle, Washington, San Diego, California, Cabo San Lucas (Baja California), Puntarenas, Panama Canal Transit, Cartagena CO, Miami, Fl
2026 Sails: May 11, More...
39 Night - The Americas & Caribbean
Starting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, San Juan del Sur, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...7 Night - Classic California Coast
Starting in San Francisco, California, Catalina Island, California, Los Angeles, California, San Diego, California, Ensenada, Mexico, San Francisco, California
2026 Sails: Sep 10, More...
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
Click on a cruise ship itinerary that visits San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Classic California CoastStarting in San Francisco, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California, San Francisco, California
2026 Sails: Apr 19, More...
18 Night - Msc Grand VoyagesStarting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...
Deal link -> Special
11 Night - Mexican Riviera & Pacific CoastStarting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 25, More...
7 Night - Pacific Wine CountryStarting in Los Angeles, California, San Diego, California, Santa Barbara, California, Astoria, Oregon, Victoria CA, Vancouver, Canada
2026 Sails: Apr 25, More...
8 Night - Pacific Coastal CruiseStarting in Los Angeles, California, San Diego, California, San Francisco, California, Victoria CA, Canada, Vancouver, British Columbia
2026 Sails: Apr 30, More...
7 Night - Pacific Wine CountryStarting in Los Angeles, California, San Diego, California, San Francisco, California, Astoria, Oregon, Victoria CA, Vancouver, Canada
2026 Sails: May 6, More...
9 Night - Wine Country CoastalStarting in Vancouver, Canada, Seattle, Washington, Astoria, Oregon, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California
2026 Sails: May 7, More...
20 Night - Seattle to MiamiStarting in Seattle, Washington, San Diego, California, Cabo San Lucas (Baja California), Puntarenas, Panama Canal Transit, Cartagena CO, Miami, Fl
2026 Sails: May 11, More...
39 Night - The Americas & CaribbeanStarting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, San Juan del Sur, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...
7 Night - Classic California CoastStarting in San Francisco, California, Catalina Island, California, Los Angeles, California, San Diego, California, Ensenada, Mexico, San Francisco, California
2026 Sails: Sep 10, More...
