San Diego Cruises
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
15 Night - MSC Grand Voyages
Starting in Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Panama Canal (Transit), Panama, Colon, Panama, Cartagena CO, Colombia, Miami
2026 Sails: Oct 2, More...
21 Night - Panama Canal
Starting in Seattle, Washington, Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...
28 Night - Circle Hawaii and Sea of Cortez
Starting in Vancouver, BC, CA, Hilo, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kona, Hawaii, Avalon, California, San Diego, California, Manzanillo, Mexico, Puerto Vallarta, Mexico, Mazatlan, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Oct 3, More...20 Night - Panama Canal
Starting in Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
11 Night - Mexican Riviera & Pacific Coast
Starting in Vancouver, BC, CA, San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Oct 4, More...
5 Night - Baja Mexico Halloween Cruise
Starting in Los Angeles, California, Catalina Island, California, San Diego, California, Ensenada, Mexico, Los Angeles, California
2026 Sails: Oct 24, More...
7 Night - Classic California Coast
Starting in Los Angeles, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, San Francisco, California, Los Angeles, California
2026 Sails: Nov 1, More...30 Night - Circle Hawaii & Sea of Cortez
Starting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Ensenada, Mexico, San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Nov 19, More...
91 Night - Round World from Civitavecchia (Rome)
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada, Praia Da Vitoria, New York, Port Everglades, Half Moon Cay, Cristobal, Panama, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete, Suva, Lifou, Noumea, Sydney AU, Newcastle AU, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Pusan, Keelung, Taiwan, Hong Kong
2026 Sails: Nov 24, More...66 Night - Round World from Civitavecchia (Rome)
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada, Praia Da Vitoria, New York, Port Everglades, Half Moon Cay, Cristobal, Panama, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete, Suva, Lifou, Noumea, Sydney AU
2026 Sails: Nov 24, More...
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
Click on a cruise ship itinerary that visits San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.
15 Night - MSC Grand VoyagesStarting in Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Panama Canal (Transit), Panama, Colon, Panama, Cartagena CO, Colombia, Miami
2026 Sails: Oct 2, More...
21 Night - Panama CanalStarting in Seattle, Washington, Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...
28 Night - Circle Hawaii and Sea of CortezStarting in Vancouver, BC, CA, Hilo, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kona, Hawaii, Avalon, California, San Diego, California, Manzanillo, Mexico, Puerto Vallarta, Mexico, Mazatlan, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Oct 3, More...
20 Night - Panama CanalStarting in Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
11 Night - Mexican Riviera & Pacific CoastStarting in Vancouver, BC, CA, San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Oct 4, More...
5 Night - Baja Mexico Halloween CruiseStarting in Los Angeles, California, Catalina Island, California, San Diego, California, Ensenada, Mexico, Los Angeles, California
2026 Sails: Oct 24, More...
7 Night - Classic California CoastStarting in Los Angeles, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, San Francisco, California, Los Angeles, California
2026 Sails: Nov 1, More...
30 Night - Circle Hawaii & Sea of CortezStarting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Ensenada, Mexico, San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Nov 19, More...
91 Night - Round World from Civitavecchia (Rome)Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada, Praia Da Vitoria, New York, Port Everglades, Half Moon Cay, Cristobal, Panama, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete, Suva, Lifou, Noumea, Sydney AU, Newcastle AU, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Pusan, Keelung, Taiwan, Hong Kong
2026 Sails: Nov 24, More...
66 Night - Round World from Civitavecchia (Rome)Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada, Praia Da Vitoria, New York, Port Everglades, Half Moon Cay, Cristobal, Panama, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete, Suva, Lifou, Noumea, Sydney AU
2026 Sails: Nov 24, More...
