Panama Canal Cruises
Cruises that visit Central America: Panama: Panama Canal
18 Night - Panama Canal Cruise : Miami, Cabo San Lucas & San Diego
Starting in Miami, Florida, Cabo Rojo, Cartagena CO, Panama Canal (Cruising), Puntarenas, Puerto Quetzal, Puerto Vallarta, San Diego, San Francisco, California
2026 Sails: Dec 18, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
15 Night - Panama Canal Holiday
Starting in San Diego, California, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Dec 19, More...
36 Night - Caribbean to Cape Horn
Starting in Miami, Key West, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Panama Canal Daylight Transit, Manta, Salaverry, Lima / Machu Picchu (Callao), Pisco / Nazca Lines, Coquimbo, Santiago De Chile (San Antonio CL), Puerto Montt, Puerto Chacabuco, Laguna San Raphael, Cruising the Chilean Fjords, Punta Arenas, Cruising Around Cape Horn, Ushuaia, Port Stanley, Falkland Islands, Puerto Madryn, Punta Del Este, Buenos Aires
2026 Sails: Dec 19, More...
15 Night - Antilles to Andes
Starting in Miami, Key West, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Panama Canal Daylight Transit, Manta, Salaverry, Lima / Machu Picchu (Callao)
2026 Sails: Dec 19, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...
19 Night - Panama Canal Holiday : Amber Cove & Costa Rica
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Grand Turk, Turks and Caicos, Amber Cove, Dominican Republic, Key West, Florida, Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Dec 20, More...
12 Night - Panama Canal - Miami
Starting in Miami, Fl, Great Stirrup Cay, Bahamas, Cabo Rojo, Dominican Republic, Oranjestad, Aruba, Willemstad AN, Netherlands Antilles, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Miami, Fl
2026 Sails: Dec 21, 2027: Jan 25, Mar 1, More...
18 Night - Miami to Los Angeles
Starting in Miami, Fl, Cartagena CO, Panama Canal Transit, Puntarenas, Puerto Quetzal, Puerto Vallarta, Jalisco, San Diego, California, Los Angeles, California
2026 Sails: Dec 21, More...
17 Night - Panama Canal & the Pacific Coast
Starting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Cartagena CO, Colon, Scenic Sailing Panama Canal, Sail the Pacific Ocean, Puntarenas (Puerto Caldera), Sail the Pacific Ocean, Cabo San Lucas, Sail the Pacific Ocean, Los Angeles, California
2026 Sails: Dec 22, More...
Cruises that visit Central America: Panama: Panama Canal
Click on a cruise ship itinerary that visits Panama Canal (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama Canal), please visit: Cruise Search or try our Virtual Cruise Advisor™.
18 Night - Panama Canal Cruise : Miami, Cabo San Lucas & San DiegoStarting in Miami, Florida, Cabo Rojo, Cartagena CO, Panama Canal (Cruising), Puntarenas, Puerto Quetzal, Puerto Vallarta, San Diego, San Francisco, California
2026 Sails: Dec 18, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
15 Night - Panama Canal HolidayStarting in San Diego, California, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Dec 19, More...
Deal link -> Special
36 Night - Caribbean to Cape HornStarting in Miami, Key West, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Panama Canal Daylight Transit, Manta, Salaverry, Lima / Machu Picchu (Callao), Pisco / Nazca Lines, Coquimbo, Santiago De Chile (San Antonio CL), Puerto Montt, Puerto Chacabuco, Laguna San Raphael, Cruising the Chilean Fjords, Punta Arenas, Cruising Around Cape Horn, Ushuaia, Port Stanley, Falkland Islands, Puerto Madryn, Punta Del Este, Buenos Aires
2026 Sails: Dec 19, More...
Deal link -> Special
15 Night - Antilles to AndesStarting in Miami, Key West, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Panama Canal Daylight Transit, Manta, Salaverry, Lima / Machu Picchu (Callao)
2026 Sails: Dec 19, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...
19 Night - Panama Canal Holiday : Amber Cove & Costa RicaStarting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Grand Turk, Turks and Caicos, Amber Cove, Dominican Republic, Key West, Florida, Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Dec 20, More...
12 Night - Panama Canal - MiamiStarting in Miami, Fl, Great Stirrup Cay, Bahamas, Cabo Rojo, Dominican Republic, Oranjestad, Aruba, Willemstad AN, Netherlands Antilles, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Miami, Fl
2026 Sails: Dec 21, 2027: Jan 25, Mar 1, More...
18 Night - Miami to Los AngelesStarting in Miami, Fl, Cartagena CO, Panama Canal Transit, Puntarenas, Puerto Quetzal, Puerto Vallarta, Jalisco, San Diego, California, Los Angeles, California
2026 Sails: Dec 21, More...
17 Night - Panama Canal & the Pacific CoastStarting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Cartagena CO, Colon, Scenic Sailing Panama Canal, Sail the Pacific Ocean, Puntarenas (Puerto Caldera), Sail the Pacific Ocean, Cabo San Lucas, Sail the Pacific Ocean, Los Angeles, California
2026 Sails: Dec 22, More...