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Panama Canal Cruises

Cruises that visit Central America: Panama: Panama Canal

Click on a cruise ship itinerary that visits Panama Canal (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama Canal), please visit: Cruise Search or try our Virtual Cruise Advisor™.



MSC Poesia Cruise Ship34 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 7, More...
Seabourn Quest Cruise Ship19 Night - Panama Canal Passage
Starting in Long Beach, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Miami, Florida
2026 Sails: Apr 7, 2027: May 11, More...
MSC Poesia Cruise Ship33 Night - Msc Grand Voyages
Starting in Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 8, More...
HAL Koningsdam Cruises22 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...
HAL Koningsdam Cruises17 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 10, More...
Carnival Miracle Cruise Ship16 Night - Journeys - Panama Canal
Starting in Tampa, Fl, Grand Cayman, Cayman Islands, Cartagena CO, Panama Canal Transit, Puntarenas, Costa Rica, Cabo San Lucas, Mexico, Seattle, Wa
2026 Sails: Apr 11, More...
NCL Norwegian Encore Cruises18 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Panama City, Panama, Transit Panama Canal / At Sea, Panama City, Panama, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Francisco, Ca
2026 Sails: Apr 11, More...
NCL Norwegian Encore Cruises22 Night - Repo - Panama Canal
Starting in Miami, Fl, Cartagena CO, Panama City, Panama, Transit Panama Canal / At Sea, Panama City, Panama, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Francisco, Ca, Astoria, Or, Victoria CA, Canada, Seattle, Wa
2026 Sails: Apr 11, More...
Carnival Spirit Cruise Ship16 Night - Journeys - Panama Canal
Starting in Mobile, Al, Cartagena CO, Panama Canal Transit, Puntarenas, Costa Rica, Cabo San Lucas, Mexico, Seattle, Wa
2026 Sails: Apr 12, 2027: Mar 29, More...
Celebrity Summit Cruise Ship17 Night - Panama Canal Westward Cruise
Starting in Fort Lauderdale, Florida, George Town, Grand Cayman, Cartagena CO, Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Mazatlan, Mexico, Los Angeles, California
2026 Sails: Apr 13, More...


Panama Canal Cruises