Panama Canal Cruises
Cruises that visit Central America: Panama: Panama Canal
34 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 7, More...
19 Night - Panama Canal Passage
Starting in Long Beach, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Miami, Florida
2026 Sails: Apr 7, 2027: May 11, More...33 Night - Msc Grand Voyages
Starting in Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 8, More...
22 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...17 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 10, More...
16 Night - Journeys - Panama Canal
Starting in Tampa, Fl, Grand Cayman, Cayman Islands, Cartagena CO, Panama Canal Transit, Puntarenas, Costa Rica, Cabo San Lucas, Mexico, Seattle, Wa
2026 Sails: Apr 11, More...
18 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Panama City, Panama, Transit Panama Canal / At Sea, Panama City, Panama, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Francisco, Ca
2026 Sails: Apr 11, More...22 Night - Repo - Panama Canal
Starting in Miami, Fl, Cartagena CO, Panama City, Panama, Transit Panama Canal / At Sea, Panama City, Panama, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Francisco, Ca, Astoria, Or, Victoria CA, Canada, Seattle, Wa
2026 Sails: Apr 11, More...
16 Night - Journeys - Panama Canal
Starting in Mobile, Al, Cartagena CO, Panama Canal Transit, Puntarenas, Costa Rica, Cabo San Lucas, Mexico, Seattle, Wa
2026 Sails: Apr 12, 2027: Mar 29, More...
17 Night - Panama Canal Westward Cruise
Starting in Fort Lauderdale, Florida, George Town, Grand Cayman, Cartagena CO, Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Mazatlan, Mexico, Los Angeles, California
2026 Sails: Apr 13, More...
Cruises that visit Central America: Panama: Panama Canal
Click on a cruise ship itinerary that visits Panama Canal (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama Canal), please visit: Cruise Search or try our Virtual Cruise Advisor™.
34 Night - Msc Grand VoyagesStarting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 7, More...
Deal link -> Special
19 Night - Panama Canal PassageStarting in Long Beach, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Miami, Florida
2026 Sails: Apr 7, 2027: May 11, More...
33 Night - Msc Grand VoyagesStarting in Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 8, More...
22 Night - Panama CanalStarting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...
17 Night - Panama CanalStarting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 10, More...
16 Night - Journeys - Panama CanalStarting in Tampa, Fl, Grand Cayman, Cayman Islands, Cartagena CO, Panama Canal Transit, Puntarenas, Costa Rica, Cabo San Lucas, Mexico, Seattle, Wa
2026 Sails: Apr 11, More...
18 Night - Panama Canal - MiamiStarting in Miami, Fl, Cartagena CO, Panama City, Panama, Transit Panama Canal / At Sea, Panama City, Panama, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Francisco, Ca
2026 Sails: Apr 11, More...
22 Night - Repo - Panama CanalStarting in Miami, Fl, Cartagena CO, Panama City, Panama, Transit Panama Canal / At Sea, Panama City, Panama, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Francisco, Ca, Astoria, Or, Victoria CA, Canada, Seattle, Wa
2026 Sails: Apr 11, More...
16 Night - Journeys - Panama CanalStarting in Mobile, Al, Cartagena CO, Panama Canal Transit, Puntarenas, Costa Rica, Cabo San Lucas, Mexico, Seattle, Wa
2026 Sails: Apr 12, 2027: Mar 29, More...
17 Night - Panama Canal Westward CruiseStarting in Fort Lauderdale, Florida, George Town, Grand Cayman, Cartagena CO, Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Mazatlan, Mexico, Los Angeles, California
2026 Sails: Apr 13, More...
