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Cusco Cruises

Cruises that visit South America: Peru: Cusco

See all River Cruises that visit Cusco

Click on a cruise ship itinerary that visits Cusco (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Cusco), please visit: Cruise Search or try our Virtual Cruise Advisor™.


MS Santa Cruz II Tours13 Night - Galapagos Islands - in Darwin's Footsteps Plus Machu Picchu
Starting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Mosquera, Puerto Baquerizo Moreno, Punta Pitt, San Cristobal Island, Santa Fe, South Plaza Island, Charles Darwin Research Station, Santa Cruz Island, Punta Suarez, Espanola Island, Gardner Bay, Espanola Island, Eden Islet, San Cristobal Island, Seymour Norte, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 13, Nov 27, Dec 11, More...
National Geographic Endeavour II Tours15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, Apr 23, More...
MS Santa Cruz II Tours15 Night - Galapagos Islands - Nine of the Best Isles Plus Machu Picchu
Starting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 19, Dec 3, More...
MS Santa Cruz II Tours11 Night - Galapagos Islands - Iconic Wildlife & Sublime Scenery Plus Machu Picchu
Starting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Fernandina, Puerto Ayora, Isla Santa Cruz, Post Office Bay, Champion Islet, Punta Cormorant, Seymour, Baltra Airport (Galapagos)
2026 Sails: Nov 19, Dec 3, Dec 17, More...
National Geographic Islander II Tours11 Night - Peru and Galapagos Escape
Starting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Guayaquil, Ecuador, Guayaquil / Baltra / Embark Ship, Baltra / Disembark Ship / Quito, Quito
2026 Sails: Nov 19, Dec 3, Dec 17, Dec 31, 2027: Jan 14, Jan 28, Feb 11, Feb 25, Mar 11, More...
National Geographic Delfina Tours15 Night - Galapagos by Catamaran, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Nov 20, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, Apr 23, May 7, May 14, May 21, May 28, More...
Delfin III Tours9 Night - Exploring Peru : Machu Picchu and the Amazon
Starting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Nov 26, Dec 3, More...
National Geographic Gemini Tours15 Night - Exploring Galapagos, Machu Picchu and Peru's Land of the Inca
Starting in Quito, Ecuador, Quito / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Quito / Lima, Peru, Lima, Lima / Cusco / Sacred Valley, Sacred Valley, Sacred Valley / Machu Picchu, Machu Picchu / Cusco, Cusco, Cusco / Lima
2026 Sails: Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, More...
MS Santa Cruz II Tours13 Night - Galapagos Islands - in Darwin's Footsteps Plus Machu Picchu
Starting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Mosquera, Punta Pitt, San Cristobal Island, Puerto Baquerizo Moreno, Santa Fe, South Plaza Island, Puerto Ayora, Isla Santa Cruz, Punta Suarez, Espanola Island, Bahia Gardner, Espanola, Islote Eden, Seymour Norte, Seymour, Baltra Airport (Galapagos)
2026 Sails: Dec 25, 2027: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jun 25, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 29, Nov 12, Nov 26, Dec 10, More...
MS Santa Cruz II Tours15 Night - Galapagos Islands - Nine of the Best Isles Plus Machu Picchu
Starting in Lima Airport, Lima, Lima Airport, Cusco Airport, Quito Airport, Quito, Quito Airport, Seymour, Dragon Hill, Punta Vicente Roca, Punta Espinoza, Fernandina Island, Puerto Ayora, Isla Santa Cruz, Baroness Tower, Floreana Island, Punta Cormorant, Seymour, Las Bachas, Santa Cruz Island, Buccaneer Cove, Puerto Egas, Rabida Island, Bartolome Island, Prince Philip Steps, Genovesa Island, Darwin Bay, Genovesa Island, Itabaca Channel, Seymour, Baltra Airport (Galapagos)
2026 Sails: Dec 31, 2027: Jan 14, Jan 28, Feb 11, Feb 25, Mar 11, Mar 25, Apr 8, Apr 22, May 6, May 20, Jun 3, Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Oct 21, Nov 4, Nov 18, Dec 2, Dec 16, More...


Cusco Cruises