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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay



MSC Cruises, MSC Poesia
MSC Poesia22 Night - Caribbean and Antilles
Starting in Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida, Montego Bay, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida
2026 Sails: Dec 23, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa3 Night - South America
Starting in Maceio, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 23, 2027: Mar 31, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema7 Night - South America Roundtrip from Montevideo
Starting in Montevideo, Uruguay, Itajai, Brazil, Santos, Brazil, Buenos Aires, Argentina, Montevideo, Uruguay
2026 Sails: Dec 24, Dec 31, 2027: Jan 7, Jan 14, Jan 21, Jan 28, Feb 18, Feb 25, Mar 4, Mar 11, More...
Costa Cruise Lines, Costa Serena
Costa Serena4 Night - South America Roundtrip from Montevideo
Starting in Montevideo, Uruguay, Punta del Este, Uruguay, Buenos Aires, Argentina, Montevideo, Uruguay
2026 Sails: Dec 24, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa7 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil, Copacabana (Rio de Janeiro), Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 26, More...
Costa Cruise Lines, Costa Serena
Costa Serena9 Night - South America Roundtrip from Buenos Aires
Starting in Buenos Aires, Argentina, Montevideo, Uruguay, Camboriu, Brazil, Abraao (Ilha Grande), Rio de Janeiro, Brazil, Ilhabela, Brazil, Buenos Aires, Argentina
2026 Sails: Dec 27, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam21 Night - Panama Canal & Southern Caribbean Holiday
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Dec 27, More...
MSC Cruises, MSC Splendida
MSC Splendida9 Night - South America
Starting in Buenos Aires, Argentina, Ilhabela, Brazil, Rio De Janeiro, Brazil, Copacabana (Rio de Janeiro), Brazil, Buzios, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina
2026 Sails: Dec 27, More...
Viking Ocean, Viking Mars
Viking Mars14 Night - Panama Canal & Central America
Starting in West Palm Beach, Florida, Sail the Caribbean Sea, Montego Bay, Sail the Caribbean Sea, Cartagena CO, Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Dec 27, More...
Costa Cruise Lines, Costa Serena
Costa Serena9 Night - South America Roundtrip from Montevideo
Starting in Montevideo, Uruguay, Camboriu, Brazil, Abraao (Ilha Grande), Rio de Janeiro, Brazil, Ilhabela, Brazil, Buenos Aires, Argentina, Montevideo, Uruguay
2026 Sails: Dec 28, More...

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South America Cruises