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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay



Costa Cruise Lines, Costa Diadema
Costa Diadema Cruises3 Night - South America Roundtrip from Santos
Starting in Santos, Brazil, Itajai, Brazil, Santos, Brazil
2026 Sails: Apr 2, Apr 9, Apr 16, More...
Queen Elizabeth Cruise Ship32 Night - Miami to Seattle
Starting in Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Cabo San Lucas, Mexico, Los Angeles, CA, Seattle, WA
2026 Sails: Apr 2, More...
Queen Elizabeth Cruise Ship42 Night - Miami to Seattle
Starting in Miami, FL, San Juan, Puerto Rico, St Johns AG, Antigua, Castries, St Lucia, Bridgetown, Barbados, Philipsburg, St Maarten, Road Town, Tortola, Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Cabo San Lucas, Mexico, Los Angeles, CA, Seattle, WA, Ketchikan, AK, Sitka, AK, Glacier Bay, AK, (Scenic Cruising), Juneau, AK, Skagway, AK, Tracy Arm Fjord, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA
2026 Sails: Apr 2, More...
MSC Cruises, MSC Preziosa
MSC Preziosa Cruises24 Night - Msc Grand Voyages
Starting in Santos (Sao Paulo), Brazil, Rio De Janeiro, Brazil, Ilheus, Brazil, Salvador, Brazil, Maceio, Brazil, Funchal (Madeira Islands), Portugal, Vigo (Santiago De Compostela), Spain, Gijon, Spain, Southampton (London), United Kingdom, Le Havre (Paris), France, Zeebrugge (Bruges), Belgium, Copenhagen, Denmark, Oslo, Norway, Hamburg, Germany
2026 Sails: Apr 2, More...
MSC Cruises, MSC Preziosa
MSC Preziosa Cruises14 Night - Msc Grand Voyages
Starting in Santos (Sao Paulo), Brazil, Rio De Janeiro, Brazil, Ilheus, Brazil, Salvador, Brazil, Maceio, Brazil, Funchal (Madeira Islands), Portugal, Vigo (Santiago De Compostela), Spain
2026 Sails: Apr 2, More...
MSC Cruises, MSC Preziosa
MSC Preziosa Cruises1 Night - South America
Starting in Santos (Sao Paulo), Brazil, Rio De Janeiro, Brazil
2026 Sails: Apr 2, More...
MSC Cruises, MSC Preziosa
MSC Preziosa Cruises17 Night - Msc Grand Voyages
Starting in Santos (Sao Paulo), Brazil, Rio De Janeiro, Brazil, Ilheus, Brazil, Salvador, Brazil, Maceio, Brazil, Funchal (Madeira Islands), Portugal, Vigo (Santiago De Compostela), Spain, Gijon, Spain, Southampton (London), United Kingdom
2026 Sails: Apr 2, More...
MSC Cruises, MSC Preziosa
MSC Preziosa Cruises12 Night - Msc Grand Voyages
Starting in Santos (Sao Paulo), Brazil, Rio De Janeiro, Brazil, Ilheus, Brazil, Salvador, Brazil, Maceio, Brazil, Funchal (Madeira Islands), Portugal
2026 Sails: Apr 2, More...
Seabourn, Seabourn Pursuit
Seabourn Pursuit Cruises19 Night - Easter & Pitcairn Islands : Marooned, Moai & Mutineers
Starting in San Antonio CL (Santiago), Chile, Juan Fernandez, Easter Island, Chile, Ducie Island, Pitcairn, Adamstown, Pitcairn Island, Pitcairn, Fakarava, Tuamotu, French Polynesia, Toau, French Polynesia, Anaa, French Polynesia, Papeete, French Polynesia
2026 Sails: Apr 2, More...
MSC Cruises, MSC Preziosa
MSC Preziosa Cruises23 Night - Msc Grand Voyages
Starting in Rio De Janeiro, Brazil, Ilheus, Brazil, Salvador, Brazil, Maceio, Brazil, Funchal (Madeira Islands), Portugal, Vigo (Santiago De Compostela), Spain, Gijon, Spain, Southampton (London), United Kingdom, Le Havre (Paris), France, Zeebrugge (Bruges), Belgium, Copenhagen, Denmark, Oslo, Norway, Hamburg, Germany
2026 Sails: Apr 3, More...

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South America Cruises