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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



Quark Expeditions Tours, World Voyager Quark Tours
World Voyager Quark Tours7 Night - Antarctic Express : Fly the Drake
Starting in Arrive in Punta Arenas, Chile, Fly to King George Island and Embarkation, Antarctic Peninsula and South Shetland Islands, Disembarkation and Fly to Punta Arenas, Depart Punta Arenas
2026 Sails: Dec 1, Dec 6, 2027: Feb 11, Feb 16, Feb 21, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity10 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puntarenas
2026 Sails: Dec 2, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity8 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City)
2026 Sails: Dec 2, More...
Lindblad Expeditions Tours, National Geographic Endurance Tours
National Geographic Endurance Tours11 Night - Voyage to Antarctica
Starting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Dec 2, Dec 12, Dec 22, 2027: Jan 1, Nov 15, Nov 25, Dec 19, Dec 29, 2028: Jan 8, Jan 18, Jan 28, Feb 7, Oct 29, Nov 8, Nov 18, Nov 28, Dec 8, 2029: Jan 1, More...
MSC Cruises, MSC Seaview
MSC Seaview3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Camboriu, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 2, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 2, More...
MSC Cruises, MSC Musica
MSC Musica3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 3, Dec 10, 2027: Mar 19, Nov 24, Dec 3, More...
MSC Cruises, MSC Splendida
MSC Splendida8 Night - South America
Starting in Buenos Aires, Argentina, Rio De Janeiro, Brazil, Ilhabela, Brazil, Camboriu, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina
2026 Sails: Dec 3, Dec 11, Dec 19, 2027: Feb 19, Feb 27, Mar 7, Mar 15, Mar 23, Dec 5, Dec 13, Dec 21, 2028: Feb 21, Feb 29, Mar 16, Mar 24, More...
MSC Cruises, MSC Splendida
MSC Splendida3 Night - South America
Starting in Buenos Aires, Argentina, Rio De Janeiro, Brazil
2026 Sails: Dec 3, More...
Scenic Luxury, Scenic Eclipse
Scenic Eclipse15 Night - Antarctica and the Weddell Sea
Starting in Buenos Aires, Buenos Aires / Ushuaia, Antarctica, At Sea / Ushuaia, Ushuaia, Argentina / Buenos Aires
2026 Sails: Dec 3, More...

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South America Cruises