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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



Oceania Cruises, Oceania Insignia
Oceania Insignia40 Night - Amazon & Tropical Isles
Starting in Lisbon, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de La Palma, San Juan, Nassau, Miami, Tortola, St Johns AG, Castries, Scarborough, Cruising the Amazon River, Santarem (Amazon River), Boca Da Valeria (Amazon River), Manaus (Amazon River), Parintins (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Bridgetown, Roseau, Philipsburg, San Juan, Nassau, Miami
2026 Sails: Nov 9, More...
Regent Seven Seas, Seven Seas Mariner
Seven Seas Mariner22 Night - Secrets of the Amazon
Starting in Miami, Cruising the Atlantic Ocean, Bridgetown, Port of Spain, Cruising the Atlantic Ocean, Cruising the Amazon River, Santarem (Amazon River), Boca Da Valeria (Amazon River), Manaus (Amazon River), Parintins (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Cruising the Atlantic Ocean, St Georges, Cruising the Caribbean Sea, San Juan, Cruising the Atlantic Ocean, Miami
2026 Sails: Nov 9, More...
Silversea, Silver Cloud
Silver Cloud15 Night - Puerto Williams to Puerto Williams
Starting in Puerto Williams, South Georgia, Drake Passage, Elephant Island, Antarctic Peninsula, South Shetland Islands, Drake Passage, Puerto Williams
2026 Sails: Nov 9, Nov 24, 2027: Feb 12, Dec 5, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema13 Night - Transatlantic from Las Palmas
Starting in Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo)
2026 Sails: Nov 10, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema12 Night - Transatlantic from Las Palmas
Starting in Las Palmas (Gran Canaria), Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro
2026 Sails: Nov 10, More...
Scenic Luxury, Scenic Eclipse II
Scenic Eclipse II21 Night - Antarctica, South Georgia & Falkland Islands
Starting in Buenos Aires, Argentina, Falkland Islands, South Georgia, Antarctica, At Sea / Ushuaia, Ushuaia, Argentina / Buenos Aires
2026 Sails: Nov 10, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema12 Night - Transatlantic from S. Cruz De Tenerife
Starting in Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro, Santos (Sao Paulo)
2026 Sails: Nov 11, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema11 Night - Transatlantic from S. Cruz De Tenerife
Starting in Santa Cruz de Tenerife, Mindelo (Sao Vicente), Maceio, Salvador Bahia, Rio De Janeiro
2026 Sails: Nov 11, More...
MSC Cruises, MSC Splendida
MSC Splendida22 Night - Msc Grand Voyages
Starting in Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Gibraltar, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Maceio, Brazil, Salvador, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 11, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Panama Canal with Costa Rica & Caribbean
Starting in Fort Lauderdale, Florida, Aruba, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Grand Cayman, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Nov 11, Dec 17, Dec 29, 2027: Feb 3, Feb 15, More...

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South America Cruises