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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



MSC Cruises, MSC Divina
MSC Divina17 Night - Msc Grand Voyages
Starting in Naples (Pompeii), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Oct 29, More...
Silversea, Silver Wind
Silver Wind9 Night - King George Island to Puerto Williams
Starting in King George Island, Antarctic Sound, Antarctic Peninsula, South Shetland Islands, Drake Passage, Puerto Williams
2026 Sails: Oct 29, 2027: Jan 15, Feb 2, Feb 20, Mar 10, Nov 13, Dec 1, Dec 19, 2028: Jan 6, Jan 24, Feb 11, Feb 29, More...
Virgin Voyages, Brilliant Lady
Brilliant Lady17 Night - Panama Canal : La to Miami Halloween
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama City, Panama, Panama Canal (Cruising), Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 29, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam21 Night - Southern Caribbean & Panama Canal : Abc Islands
Starting in Fort Lauderdale, Florida, Cabo Rojo, Dominican Republic, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Ocho Rios, Jamaica, Fort Lauderdale, Florida
2026 Sails: Oct 30, More...
Lindblad Expeditions Tours, National Geographic Explorer Tours
National Geographic Explorer Tours20 Night - Antarctica, South Georgia, and the Falklands
Starting in Buenos Aires, Argentina, Ushuaia / Embark Ship, Falkland Islands, South Georgia Island, Antarctica, Disembark Ship / Ushuaia / Buenos Aires
2026 Sails: Oct 30, More...
MSC Cruises, MSC Divina
MSC Divina17 Night - Msc Grand Voyages
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Oct 30, More...
MSC Cruises, MSC Divina
MSC Divina16 Night - Msc Grand Voyages
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Oct 30, More...
PONANT, L'Austral
L'Austral5 Night - Ocean Voyage : Callao - Valparaiso
Starting in Callao, Valparaiso
2026 Sails: Oct 30, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Caribbean with Costa Rica, Celebration Key & Panama Canal
Starting in Fort Lauderdale, Florida, Curacao, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Celebration Key, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 30, 2027: Jan 10, More...
Lindblad Expeditions, National Geographic Quest
National Geographic Quest7 Night - Panama and Colombia : Exploring the Caribbean Coast
Starting in Panama City, Panama / Balboa / Embark Ship, Gatun Lake / Barro Colorado / Panama Canal Crossing, Portobelo, Guna Yala Archipelago, Capurgana and Sapzurro, Colombia, Santa Cruz de Lorica / San Antero / Tuchin, Cispata Bay / Sanguare Natural Reserve, Cartagena CO, Colombia / Disembark Ship
2026 Sails: Oct 31, More...

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South America Cruises