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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Viking Ocean, Viking Neptune
Viking Neptune21 Night - Mediterranean & Adriatic Sojourn
Starting in Barcelona, Tarragona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina), Zadar, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Sep 26, More...
Viking Ocean, Viking Neptune
Viking Neptune14 Night - Mediterranean & Italian Sojourn
Starting in Barcelona, Tarragona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Sep 26, More...
Viking Ocean, Viking Neptune
Viking Neptune7 Night - Iconic Western Mediterranean
Starting in Barcelona, Tarragona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Sep 26, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema6 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Spain, Cadiz, Spain, Lisbon, Portugal, Gibraltar (UK), Malaga, Spain
2026 Sails: Sep 28, More...
Costa Cruise Lines, Costa Diadema
Costa Diadema11 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Spain, Cadiz, Spain, Lisbon, Portugal, Gibraltar (UK), Malaga, Spain, Cartagena ES, Spain, Marseille, France, Savona, Italy, Barcelona, Spain
2026 Sails: Sep 28, More...
Emerald Cruises, Emerald Sakara
Emerald Sakara10 Night - Pearls of Southern Spain & Portugal
Starting in Barcelona, Spain, Mahon, Menorca, Spain, Palma De Mallorca, Spain, Ibiza, Spain, Cartagena ES, Malaga, Spain, Tangier, Morocco, Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: Sep 28, More...
Explora Journeys, EXPLORA I
EXPLORA I14 Night - An Extended Journey of Sunlit Discovery & Timeless Wonder
Starting in Barcelona, Ibiza, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome), La Spezia, Monte Carlo, Saint-Tropez, Mahon (Menorca), Valencia, Barcelona
2026 Sails: Sep 28, More...
Regent Seven Seas, Seven Seas Voyager
Seven Seas Voyager12 Night - Mediterranean Nights
Starting in Barcelona, Toulon, La Spezia (Cinque Terre), Cruising the Tyrrhenian Sea, Valletta, Cruising the Tyrrhenian Sea, Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Sep 28, More...
Silversea, Silver Ray
Silver Ray10 Night - Barcelona to Monte Carlo
Starting in Barcelona, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Palma De Mallorca, Palamos, Marseille, Saint Tropez, Monte Carlo
2026 Sails: Sep 28, More...
Silversea, Silver Ray
Silver Ray20 Night - Southern Europe from Barcelona to Rome (Civitavecchia)
Starting in Barcelona, Malaga, Cartagena ES, Valencia, Palma De Mallorca, Palamos, Marseille, Saint Tropez, Monte Carlo, Toulon, Ajaccio, Porto Santo Stefano, Portoferraio, Livorno, Portofino, Trapani, Naples, Civitavecchia
2026 Sails: Sep 28, More...

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Spain Cruise Departures