Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

See all River Cruises that depart from Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

7 Night - Balearic & Riviera Resorts
Starting in Rome (Civitavecchia), Florence / Pisa / Tuscany (Livorno), Porto Torres (Sardinia), Mahon (Menorca), Barcelona, Sete, Toulon, Monte Carlo
2026 Sails: Oct 12, More...

Ritz-Carlton, Evrima

5 Night - Rome (Civitavecchia) / Monte Carlo
Starting in Rome (Civitavecchia), Portoferraio, Elba, Livorno, Portofino, Saint-Tropez, Monte Carlo
2026 Sails: Oct 12, More...

Oceania Cruises, Oceania Insignia

10 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Sorrento / Capri, Messina (Sicily), Valletta, Crotone (Calabria), Corfu, Kotor, Dubrovnik, Croatia, Zadar, Koper, Venice (Fusina)
2026 Sails: Oct 13, More...

Ritz-Carlton, Ilma

7 Night - Rome (Civitavecchia) / Barcelona
Starting in Rome (Civitavecchia), Livorno, Monte Carlo, Saint-Tropez, Palma de Mallorca, Mallorca, Balearic Islands, Barcelona
2026 Sails: Oct 13, More...

Viking Ocean, Viking Jupiter

Deal link -> Special

7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Oct 14, 2027: Oct 2, 2028: Jun 17, Jul 29, More...

Viking Ocean, Viking Sea

Deal link -> Special

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Oct 16, More...

SeaDream Yacht Club, SeaDream I

7 Night - Southern Italy Dream Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Porto Cervo, Sardinia, Positano, Amalfi, Lipari, Aeolian Islands, Taormina (Mount Etna) Sicily, Valletta
2026 Sails: Oct 17, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Italy, Croatia & Malta Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Valletta, Malta, Dubrovnik, Croatia, Split, Croatia, Ravenna, Italy
2026 Sails: Oct 19, More...

Viking Ocean, Viking Mira

Deal link -> Special

7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Oct 21, 2027: Oct 17, More...

Royal Caribbean, Legend of the Seas

3 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Oct 22, 2027: Oct 28, More...

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