Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

See all River Cruises that depart from Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

11 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise Tour
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2026 Sails: Aug 27, More...

Celebrity Cruises, Celebrity Ascent

10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Olympia (Katakolon), Greece, Corfu, Greece, Montenegro, Split, Croatia, Dubrovnik, Croatia, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 28, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Aug 31, More...

Virgin Voyages, Scarlet Lady

10 Night - Rome, Florence, Mykonos & More
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Catania, Sicily, Italy, Chania (Souda Bay), Crete, Greece, Santorini, Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Aug 31, More...

Windstar Tours, Wind Surf Tours

10 Night - Vatican & Croatian Coastlines Cruise Tour
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Aug 31, More...

Windstar, Wind Surf

8 Night - Classic Italy & Dalmatian Coast
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Sep 2, More...

Ritz-Carlton, Ilma

7 Night - Rome (Civitavecchia) / Venice
Starting in Rome (Civitavecchia), Gallipoli, Kotor, Korcula, Dubrovnik, Croatia, Zadar, Venice
2026 Sails: Sep 3, More...

SeaDream Yacht Club, SeaDream I

7 Night - Southern Italy Dream Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Porto Cervo, Sardinia, Positano, Amalfi, Lipari, Aeolian Islands, Taormina (Mount Etna) Sicily, Valletta
2026 Sails: Sep 5, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Italy, Spain & French Riviera
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Santa Margherita, Italy, Cannes, France, Provence (Marseille), France, Valencia, Spain, Barcelona, Spain
2026 Sails: Sep 7, More...

Viking Ocean, Viking Vesta

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Sep 8, More...

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