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Prague Cruise Departures

Cruises that depart from Europe: Czech Republic: Prague

Cruises that visit Prague

See all River Cruises that depart from Prague

Click on a cruise ship itinerary sailing from Prague (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Prague), please visit: Cruise Search or try our Virtual Cruise Advisor™.



AmaWaterways Cruise Tours, AmaSonata Cruise Tours
AmaSonata Cruise Tours10 Night - Iconic Christmas Markets with Prague Pre-Cruise
Starting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2025 Sails: Dec 14, More...
Avalon Waterways Cruise Tours, Avalon Envision Cruise Tours
Envision Cruises8 Night - Christmastime On the Danube with in Prague (Eastbound)
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Regensburg, Passau, Melk, Austria, Vienna, Vienna (Disembarkation)
2025 Sails: Dec 14, More...
Avalon Waterways Cruise Tours, Avalon Expression Cruise Tours
Avalon Expression Cruises8 Night - Christmastime On the Danube with in Prague (Eastbound)
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Regensburg, Passau, Melk, Austria, Vienna, Vienna (Disembarkation)
2025 Sails: Dec 15, 2026: Dec 12, More...
Scenic Luxury Cruises, Scenic Jade
Scenic Jade Cruises17 Night - Christmas & New Year with Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam
2025 Sails: Dec 16, More...
Scenic Luxury Cruises, Scenic Jade
Scenic Jade Cruises20 Night - Christmas & New Year with Paris & Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam / Paris, Paris
2025 Sails: Dec 16, More...
AmaWaterways Cruise Tours, AmaMora Cruise Tours
AmaMora Cruise Tours10 Night - Iconic Christmas Markets with Prague Pre-Cruise
Starting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2025 Sails: Dec 17, 2026: Nov 25, More...
Scenic Luxury Cruises, Scenic Opal
Scenic Opal Cruises17 Night - Christmas & New Year with Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Salzburg or Cesky Krumlov, Regensburg, Nuremberg, Bamberg, Wurzburg, Rudesheim / Rhine Gorge, Cologne, Amsterdam
2025 Sails: Dec 18, More...
Scenic Luxury Cruises, Scenic Opal
Scenic Opal Cruises20 Night - Christmas & New Year with Paris & Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Salzburg or Cesky Krumlov, Regensburg, Nuremberg, Bamberg, Wurzburg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Amsterdam / Paris, Paris
2025 Sails: Dec 18, More...
AmaWaterways Cruise Tours, AmaReina Cruise Tours
AmaReina Cruise Tours10 Night - Legendary Danube with Prague Pre-Cruise
Starting in Prague, Pilzen, Nuremberg, Regensburg, Passau, Melk, Wachau Valley, Vienna, Budapest
2025 Sails: Dec 21, 2026: May 10, Jun 7, 2027: Mar 21, May 2, May 16, May 30, Jun 13, Jun 27, Jul 11, More...
Scenic Luxury Cruises, Scenic Amber
Scenic Amber Cruises17 Night - Jewels of Europe with Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam
2026 Sails: Feb 20, More...

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Prague Cruise Departures