Prague Cruise Departures
Cruises that depart from Europe: Czech Republic: Prague
Cruises that visit Prague
See all River Cruises that depart from Prague
20 Night - Grand Danube Cruise with Prague Pre-Cruise and Istanbul Post-Cruise
Starting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Istanbul
2026 Sails: Sep 18, More...21 Night - Grand Danube Cruise with Prague Pre-Cruise and Brasov, Bucharest Post-Cruise
Starting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Bucharest
2026 Sails: Sep 18, More...
10 Night - Romantic Danube with Prague Pre-Cruise
Starting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Budapest
2026 Sails: Sep 23, Oct 7, Oct 21, 2027: Mar 10, Mar 24, Apr 21, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, More...
17 Night - Prague & Splendours of Europe
Starting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam
2026 Sails: Sep 24, 2027: Jul 1, More...
10 Night - Prague Adventure and Classical Danube Cruise
Starting in Prague, Passau, Linz, Emmersdorf, Vienna, Esztergom, Budapest
2026 Sails: Oct 1, More...
20 Night - Grand Danube (Smithsonian Journeys) with Prague Pre-Cruise and Istanbul Post-Cruise
Starting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Istanbul
2026 Sails: Oct 2, 2027: Jun 11, Oct 1, More...21 Night - Grand Danube (Smithsonian Journeys) with Prague Pre-Cruise and Brasov, Bucharest Post-Cruise
Starting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Bucharest
2026 Sails: Oct 2, More...
24 Night - Eastern European Escapade & Splendours of Europe
Starting in Prague, Prague / Dresden / Berlin, Berlin, Berlin / Warsaw, Warsaw, Warsaw / Krakow, Krakow / Auschwitz, Krakow / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam
2026 Sails: Oct 7, More...
17 Night - Prague & Splendours of Europe
Starting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam
2026 Sails: Oct 9, More...
9 Night - Delightful Danube & Prague
Starting in Prague, Prague, Transfer to Regensburg, Regensburg, Passau, Linz, Durnstein, Vienna, Budapest
2026 Sails: Oct 9, Oct 23, More...
Cruises that depart from Europe: Czech Republic: Prague
Cruises that visit Prague
See all River Cruises that depart from Prague
Click on a cruise ship itinerary sailing from Prague (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Prague), please visit: Cruise Search or try our Virtual Cruise Advisor™.
20 Night - Grand Danube Cruise with Prague Pre-Cruise and Istanbul Post-CruiseStarting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Istanbul
2026 Sails: Sep 18, More...
21 Night - Grand Danube Cruise with Prague Pre-Cruise and Brasov, Bucharest Post-CruiseStarting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Bucharest
2026 Sails: Sep 18, More...
10 Night - Romantic Danube with Prague Pre-CruiseStarting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Budapest
2026 Sails: Sep 23, Oct 7, Oct 21, 2027: Mar 10, Mar 24, Apr 21, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, More...
17 Night - Prague & Splendours of EuropeStarting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam
2026 Sails: Sep 24, 2027: Jul 1, More...
10 Night - Prague Adventure and Classical Danube CruiseStarting in Prague, Passau, Linz, Emmersdorf, Vienna, Esztergom, Budapest
2026 Sails: Oct 1, More...
20 Night - Grand Danube (Smithsonian Journeys) with Prague Pre-Cruise and Istanbul Post-CruiseStarting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Istanbul
2026 Sails: Oct 2, 2027: Jun 11, Oct 1, More...
21 Night - Grand Danube (Smithsonian Journeys) with Prague Pre-Cruise and Brasov, Bucharest Post-CruiseStarting in Prague, Regensburg, Villany, Passau, Linz, Weissenkirchen, Vienna, Bratislava, Budapest, Mohacs, Vukovar, Belgrade, Golubac, Vidin, Rousse, Giurgiu, Bucharest
2026 Sails: Oct 2, More...
24 Night - Eastern European Escapade & Splendours of EuropeStarting in Prague, Prague / Dresden / Berlin, Berlin, Berlin / Warsaw, Warsaw, Warsaw / Krakow, Krakow / Auschwitz, Krakow / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam
2026 Sails: Oct 7, More...
17 Night - Prague & Splendours of EuropeStarting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam
2026 Sails: Oct 9, More...
9 Night - Delightful Danube & PragueStarting in Prague, Prague, Transfer to Regensburg, Regensburg, Passau, Linz, Durnstein, Vienna, Budapest
2026 Sails: Oct 9, Oct 23, More...
