Prague Cruise Departures
Cruises that depart from Europe: Czech Republic: Prague
Cruises that visit Prague
See all River Cruises that depart from Prague
10 Night - Iconic Christmas Markets with Prague Pre-Cruise
Starting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2026 Sails: Dec 11, 2027: Dec 17, More...
11 Night - Christmastime from Nuremberg to Basel with in Prague
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Bamberg, Wurzburg, Miltenberg, Frankfurt Excursion to Rudesheim, Speyer Excursion to Heidelberg, Strasbourg, France, Breisach, Germany Excursion to Black Forest, Basel, Switzerland (Disembarkation)
2026 Sails: Dec 11, More...7 Night - Christmastime in the Heart of Germany with in Prague
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Bamberg, Wurzburg, Miltenberg, Frankfurt (Disembarkation)
2026 Sails: Dec 11, More...
10 Night - Danube Christmas Markets with Prague
Starting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Brandstatt / Passau, Regensburg
2026 Sails: Dec 11, More...
8 Night - Christmastime On the Danube with in Prague (Eastbound)
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Regensburg, Passau, Melk, Austria, Vienna, Vienna (Disembarkation)
2026 Sails: Dec 12, More...
10 Night - Gems of the Danube with Prague
Starting in Prague, Prague / Regensburg, Regensburg, Passau / Schlogen, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: Dec 12, 2027: Sep 25, Oct 9, Dec 11, More...
10 Night - Iconic Christmas Markets with Prague Pre-Cruise
Starting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2026 Sails: Dec 13, 2027: Dec 5, More...17 Night - Christmas & New Year with Prague
Starting in Prague, Prague / Budapest, Budapest, Cruising Day, Vienna, Durnstein / Melk, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Cruising Day, Rudesheim, Cologne, Amsterdam
2026 Sails: Dec 19, More...20 Night - Christmas & New Year with Paris & Prague
Starting in Prague, Prague / Budapest, Budapest, Cruising Day, Vienna, Durnstein / Melk, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Cruising Day, Rudesheim, Cologne, Amsterdam, Amsterdam / Paris, Paris
2026 Sails: Dec 19, More...
10 Night - Romantic Danube (Wine Cruise) with Prague Pre-Cruise
Starting in Prague, Regensburg, Vilshofen, Passau, Linz, Wachau Valley, Weissenkirchen, Krems, Vienna, Budapest
2027 Sails: Feb 17, Mar 3, Mar 31, Jul 21, Aug 4, Nov 10, More...
Cruises that depart from Europe: Czech Republic: Prague
Cruises that visit Prague
See all River Cruises that depart from Prague
Click on a cruise ship itinerary sailing from Prague (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Prague), please visit: Cruise Search or try our Virtual Cruise Advisor™.
10 Night - Iconic Christmas Markets with Prague Pre-CruiseStarting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2026 Sails: Dec 11, 2027: Dec 17, More...
11 Night - Christmastime from Nuremberg to Basel with in PragueStarting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Bamberg, Wurzburg, Miltenberg, Frankfurt Excursion to Rudesheim, Speyer Excursion to Heidelberg, Strasbourg, France, Breisach, Germany Excursion to Black Forest, Basel, Switzerland (Disembarkation)
2026 Sails: Dec 11, More...
7 Night - Christmastime in the Heart of Germany with in PragueStarting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Bamberg, Wurzburg, Miltenberg, Frankfurt (Disembarkation)
2026 Sails: Dec 11, More...
10 Night - Danube Christmas Markets with PragueStarting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Brandstatt / Passau, Regensburg
2026 Sails: Dec 11, More...
8 Night - Christmastime On the Danube with in Prague (Eastbound)Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Regensburg, Passau, Melk, Austria, Vienna, Vienna (Disembarkation)
2026 Sails: Dec 12, More...
10 Night - Gems of the Danube with PragueStarting in Prague, Prague / Regensburg, Regensburg, Passau / Schlogen, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: Dec 12, 2027: Sep 25, Oct 9, Dec 11, More...
10 Night - Iconic Christmas Markets with Prague Pre-CruiseStarting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2026 Sails: Dec 13, 2027: Dec 5, More...
17 Night - Christmas & New Year with PragueStarting in Prague, Prague / Budapest, Budapest, Cruising Day, Vienna, Durnstein / Melk, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Cruising Day, Rudesheim, Cologne, Amsterdam
2026 Sails: Dec 19, More...
20 Night - Christmas & New Year with Paris & PragueStarting in Prague, Prague / Budapest, Budapest, Cruising Day, Vienna, Durnstein / Melk, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Cruising Day, Rudesheim, Cologne, Amsterdam, Amsterdam / Paris, Paris
2026 Sails: Dec 19, More...
10 Night - Romantic Danube (Wine Cruise) with Prague Pre-CruiseStarting in Prague, Regensburg, Vilshofen, Passau, Linz, Wachau Valley, Weissenkirchen, Krems, Vienna, Budapest
2027 Sails: Feb 17, Mar 3, Mar 31, Jul 21, Aug 4, Nov 10, More...
