Travel Agents Competing To Offer The Best Cruise Deals
1
Find your cruise
& request quotes
2
Compare personalized offers
prices, upgrades, cabin credits & more
3
Contact your preferred agent
for questions or to book your cruise
Trusted by more than 1.5 million consumers since 2003.
Join Now
Portland ME River Cruise Departures

River Cruises that depart from North America: United States: Maine: Portland ME

River Cruises that visit Portland ME

See all Cruises that depart from Portland ME

US East Coast Cruises

Click on a cruise ship itinerary sailing from Portland ME (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Portland ME), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Cruise Lines, American Legend
American Legend Cruises8 Night - Maine Coast & Harbors Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Boothbay Harbor, ME, Rockland, ME / Camden, ME, Bar Harbor, Me, Bucksport, ME, Bangor ME
2026 Sails: Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, More...
American Cruise Lines, American Maverick
American Maverick Cruises8 Night - Maine Coast & Harbors Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Boothbay Harbor, ME, Rockland, ME / Camden, ME, Bar Harbor, Me, Bucksport, ME, Bangor ME
2026 Sails: Jul 17, Jul 31, Aug 14, 2027: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, 2028: Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, More...
American Cruise Lines, American Patriot
American Patriot Cruises8 Night - Maine Coast & Harbors Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Boothbay Harbor, ME, Rockland, ME / Camden, ME, Bar Harbor, Me, Bucksport, ME, Bangor ME
2026 Sails: Sep 18, More...
American Cruise Lines, American Patriot
American Patriot Cruises15 Night - New England Fall Foliage Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Portsmouth NH, Gloucester, MA, Boston, Ma, Marthas Vineyard, MA, Nantucket Island, MA, Newport, Ri, Sag Harbor, NY, New London / Mystic, CT, Sleepy Hollow, NY, New York, NY
2026 Sails: Oct 2, 2028: Oct 6, More...
American Cruise Lines, American Mariner
American Mariner Cruises8 Night - Maine Coast & Harbors Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Boothbay Harbor, ME, Rockland, ME / Camden, ME, Bar Harbor, Me, Bucksport, ME, Bangor ME
2027 Sails: May 29, Jun 12, Jun 26, Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, 2028: May 8, May 22, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, More...
American Cruise Lines, American Mariner
American Mariner Cruises15 Night - New England Fall Foliage Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Portsmouth NH, Gloucester, MA, Boston, Ma, Marthas Vineyard, MA, Nantucket Island, MA, Newport, Ri, Sag Harbor, NY, New London / Mystic, CT, Sleepy Hollow, NY, New York, NY
2027 Sails: Sep 18, 2028: Sep 11, More...
American Cruise Lines, American Maverick
American Maverick Cruises14 Night - New England Fall Foliage Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Portsmouth NH, Gloucester, MA, Boston, Ma, Marthas Vineyard, MA, Nantucket Island, MA, Newport, Ri, Sag Harbor, NY, New London / Mystic, CT, Sleepy Hollow, NY, New York, NY
2027 Sails: Oct 4, More...
American Cruise Lines, American Maverick
American Maverick Cruises15 Night - New England Fall Foliage Cruise
Starting in Portland ME, Day of Cruising the Maine Coast, Bath, ME, Portsmouth NH, Gloucester, MA, Boston, Ma, Marthas Vineyard, MA, Nantucket Island, MA, Newport, Ri, Sag Harbor, NY, New London / Mystic, CT, Sleepy Hollow, NY, New York, NY
2028 Sails: Sep 18, More...

Portland ME River Cruise Departures