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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

EXPLORA II7 Night - A Journey of Lush Landscapes & Golden Enchantment
Starting in Piraeus (Athens), Paros, Rhodes, Corfu, Hvar, Rijeka, Fusina (Venice)
2026 Sails: Sep 14, Oct 5, More...
EXPLORA II14 Night - An Extended Journey of Marble Cities & Sapphire Seas
Starting in Piraeus (Athens), Paros, Rhodes, Corfu, Hvar, Rijeka, Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Kotor, Milos, Piraeus (Athens)
2026 Sails: Sep 14, Oct 5, More...
Oceania Cruises, Oceania Allura
Oceania Allura12 Night - Artifacts & Antiquities
Starting in Rome (Civitavecchia), Amalfi / Positano, Salerno, Cagliari (Sardinia), Trapani (Sicily), Valletta, Agios Nikolaos (Crete), Milos, Ephesus (Kusadasi), Skiathos, Istanbul
2026 Sails: Sep 14, More...
Silversea, Silver Muse
Silver Muse10 Night - Civitavecchia to Fusina
Starting in Civitavecchia (Rome), Naples, Palermo, Sicily, Giardini Naxos (Sicily), Kotor, Bari, Dubrovnik, Croatia, Hvar, Zadar, Fusina (Venice)
2026 Sails: Sep 14, More...
Crystal Serenity7 Night - Europe & Mediterranean
Starting in Athens (Piraeus), Santorini, Bodrum, Valletta, Trapani, Cagliari (Sardinia), Civitavecchia (Rome)
2026 Sails: Sep 15, More...
Crystal Serenity4 Night - Europe & Mediterranean
Starting in Athens (Piraeus), Santorini, Bodrum, Valletta
2026 Sails: Sep 15, More...
Princess Cruises, Enchanted Princess
Enchanted Princess10 Night - Mediterranean with Greek Isles & Italy
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Dubrovnik, Croatia, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Heraklion), Greece, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 15, More...
Princess Cruises, Enchanted Princess
Enchanted Princess21 Night - The Best of the Mediterranean
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Dubrovnik, Croatia, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Heraklion), Greece, Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Kusadasi, Turkey (for Ephesus), Istanbul, Turkey, Rhodes, Greece, Sicily (Messina), Italy, Valletta, Malta, Civitavecchia (for Rome), Italy
2026 Sails: Sep 15, More...
Ritz-Carlton, Ilma
Ilma7 Night - Venice / Venice
Starting in Venice, Dubrovnik, Croatia, Kotor, Hvar, Zadar, Piran, Venice
2026 Sails: Sep 15, More...
Viking Sea7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona (Tarragona)
2026 Sails: Sep 15, More...

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Mediterranean Cruise Departures