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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa7 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome), Ajaccio (Corsica), Savona
2026 Sails: Sep 13, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa5 Night - Western Mediterranean from Taranto
Starting in Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome)
2026 Sails: Sep 13, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Savona
Starting in Savona, La Seyne (St Tropez), Palma De Mallorca, Alicante, Olbia (costa Smeralda), Civitavecchia (Rome), Savona
2026 Sails: Sep 13, More...
Norwegian Cruise Line, Norwegian Pearl
Norwegian Pearl7 Night - Europe
Starting in Piraeus / Athens, Greece, Mykonos, Greece, Olympia / Katakolon, Greece, Corfu, Greece, Kotor, Montenegro, Zadar, Croatia, Koper, Slovenia, Venice (Ravenna), Italy
2026 Sails: Sep 13, More...
Oceania Cruises, Oceania Nautica
Oceania Nautica10 Night - Dazzling Mediterranean
Starting in Rome (Civitavecchia), Sorrento / Capri, Messina (Sicily), Valletta, Dubrovnik, Croatia, Kotor, Corfu, Katakolon, Santorini, Athens (Piraeus)
2026 Sails: Sep 13, More...
Seabourn, Seabourn Quest
Seabourn Quest21 Night - Grecian Gems, Ephesus & Dalmatian Delights
Starting in Piraeus (Athens), Greece, Mykonos, Greece, Agios Nikolaos, Crete, Greece, Symi, Greece, Kos, Greece, Kusadasi (Ephesus), Turkey, Piraeus (Athens), Greece, Santorini, Greece, Monemvasia, Greece, Itea (Delphi), Greece, Nydri, Lefkada, Greece, Sarande, Albania, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Split, Croatia, Vis Island, Croatia, Zadar, Croatia, Dubrovnik, Croatia
2026 Sails: Sep 13, More...
Seabourn, Seabourn Quest
Seabourn Quest14 Night - Grecian Gems, Ephesus & Dalmatian Delights
Starting in Piraeus (Athens), Greece, Mykonos, Greece, Agios Nikolaos, Crete, Greece, Symi, Greece, Kos, Greece, Kusadasi (Ephesus), Turkey, Piraeus (Athens), Greece, Santorini, Greece, Monemvasia, Greece, Itea (Delphi), Greece, Nydri, Lefkada, Greece, Sarande, Albania, Dubrovnik, Croatia
2026 Sails: Sep 13, More...
Seabourn, Seabourn Quest
Seabourn Quest7 Night - Ephesus & Greek Island Gems
Starting in Piraeus (Athens), Greece, Mykonos, Greece, Agios Nikolaos, Crete, Greece, Symi, Greece, Kos, Greece, Kusadasi (Ephesus), Turkey, Piraeus (Athens), Greece
2026 Sails: Sep 13, More...
Queen Victoria7 Night - France and Italy
Starting in Civitavecchia (tours to Rome), Italy, Marseille, France, Villefranche, France, Genoa, Italy, La Spezia (tours to Florence or Pisa), Italy, Civitavecchia (tours to Rome), Italy
2026 Sails: Sep 14, More...
Queen Victoria14 Night - Istanbul, Greek Islands and Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, Marseille, France, Villefranche, France, Genoa, Italy, La Spezia (tours to Florence or Pisa), Italy, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Rhodes, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey
2026 Sails: Sep 14, More...

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Mediterranean Cruise Departures