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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Royal Caribbean, Explorer of the Seas
Explorer of the Seas7 Night - Greece & Croatia Cruise
Starting in Ravenna, Italy, Dubrovnik, Croatia, Athens (Piraeus), Greece, Santorini, Greece, Split, Croatia, Ravenna, Italy
2026 Sails: Jun 27, Jul 25, Sep 19, More...
SeaDream Yacht Club, SeaDream I
SeaDream I7 Night - Southern Italy Dream Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Ponza, Capri, Amalfi, Lipari, Aeolian Islands, Syracuse IT, Sicily, Valletta
2026 Sails: Jun 27, More...
Star Clippers, Royal Clipper
Royal Clipper7 Night - Croatia & Montenegro
Starting in Venice, Italy, Pesaro, Italy, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Komiza / Vis, Croatia, Rovinj, Croatia, Venice, Italy
2026 Sails: Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, More...
Celestyal Cruises, Celestyal Journey
Celestyal Journey7 Night - Idyllic Greece
Starting in Kusadasi, Rhodes, Agios Nikolaos, Crete, Santorini, Mykonos, Milos, Piraeus, Athens, Kusadasi
2026 Sails: Jun 28, Jul 5, Jul 12, Jul 19, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, 2027: May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Sep 5, Sep 12, Sep 19, Sep 26, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa7 Night - Eastern Mediterranean from Taranto
Starting in Taranto, Argostoli (Cephalonia), Mykonos, Piraeus (Athens), Malta / La Valletta, Catania, Taranto
2026 Sails: Jun 28, Jul 12, Jul 26, Aug 23, Sep 6, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Eastern Mediterranean from Istanbul
Starting in Istanbul, Mykonos, Heraklion (Crete), Rhodes, Thira (Santorini), Piraeus (Athens), Istanbul
2026 Sails: Jun 28, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Ibiza, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome), Savona
2026 Sails: Jun 28, More...
Holland America, Oosterdam
Oosterdam7 Night - Mediterranean : Greece to Turkey
Starting in Piraeus (Athens), Greece, Thira (Santorini), Greece, Souda (Chania), Greece, Kusadasi (Ephesus), Turkey, Rhodes, Greece, Mykonos, Greece, Piraeus (Athens), Greece
2026 Sails: Jun 28, More...
MSC Cruises, MSC Armonia
MSC Armonia7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy
2026 Sails: Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, 2027: May 2, May 9, May 16, May 23, Jun 6, Jun 13, More...
MSC Cruises, MSC Meraviglia
MSC Meraviglia7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy
2026 Sails: Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, More...

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Mediterranean Cruise Departures