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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Ibiza, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome)
2026 Sails: Jun 27, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Jun 27, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda5 Night - Western Mediterranean from Savona to Palermo
Starting in Savona, Marseille, Barcelona, Ibiza, Palermo
2026 Sails: Jun 27, More...
Emerald Cruises, Emerald Azzurra
Emerald Azzurra7 Night - Istanbul to Athens Adventure
Starting in Istanbul, Turkey, Cruise the Dardanelles / Kepez, Turkey, Kusadasi, Turkey, Patmos, Greece, Delos, Greece / Mykonos, Greece, Santorini, Greece, Milos, Greece, Athens (Piraeus), Greece
2026 Sails: Jun 27, More...
MSC Cruises, MSC Armonia
MSC Armonia7 Night - Mediterranean
Starting in Split, Croatia, Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy, Split, Croatia
2026 Sails: Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Oct 3, Oct 10, Oct 17, Oct 24, 2027: May 1, May 8, May 15, May 22, Jun 5, Jun 12, Jun 26, More...
MSC Cruises, MSC Lirica
MSC Lirica7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy, Venice / Marghera, Italy
2026 Sails: Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, 2027: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, More...
MSC Cruises, MSC Meraviglia
MSC Meraviglia7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, More...
MSC Cruises, MSC Seaview
MSC Seaview7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Jun 27, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia7 Night - Mediterranean
Starting in Bari, Italy, Santorini, Greece, Piraeus (Athens), Greece, Katakolon (Olympia), Greece, Cefalonia / Argostoli, Greece, Corfu, Greece, Bari, Italy
2026 Sails: Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, More...
PONANT, Le Ponant
Le Ponant7 Night - The Cyclades, in the Wake Of
Starting in Athens (Lavrio), Polyaigos, Tinos, Cesme, Serifos, Kythnos, Spetses, Athens (Lavrio)
2026 Sails: Jun 27, More...

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Mediterranean Cruise Departures