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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa14 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Zakynthos, Argostoli (Cephalonia), Dubrovnik, Croatia, Split, Marghera (Venice), Bari, Thira (Santorini), Mykonos, Argostoli (Cephalonia), Marghera (Venice)
2026 Sails: Sep 12, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Zakynthos, Argostoli (Cephalonia), Dubrovnik, Croatia, Split, Marghera (Venice)
2026 Sails: Sep 12, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa10 Night - Western Mediterranean from Catania
Starting in Catania, Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome), Ajaccio (Corsica), Savona, Marseille, Barcelona
2026 Sails: Sep 12, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa6 Night - Western Mediterranean from Catania
Starting in Catania, Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome)
2026 Sails: Sep 12, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa8 Night - Western Mediterranean from Catania
Starting in Catania, Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome), Ajaccio (Corsica), Savona
2026 Sails: Sep 12, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Alicante, Olbia (costa Smeralda), Civitavecchia (Rome)
2026 Sails: Sep 12, More...
Queen Anne8 Night - Western Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, La Spezia (tours to Florence or Pisa), Italy, Marseille, France, Malaga (tours to Granada), Spain, Gibraltar, Southampton, England, UK
2026 Sails: Sep 12, More...
Princess Cruises, Sun Princess
Sun Princess14 Night - Western Mediterranean with Greece & Italy
Starting in Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Sep 12, More...
Seven Seas Navigator10 Night - Grecian Myths
Starting in Venice (Fusina), Rijeka, Cruising the Mediterranean Sea, Zadar, Dubrovnik, Croatia, Kotor, Sarande, Cruising the Ionian Sea, Zakynthos, Gythion, Athens (Piraeus)
2026 Sails: Sep 12, More...
Ritz-Carlton, Evrima
Evrima7 Night - Rome (Civitavecchia) / Athens (Piraeus)
Starting in Rome (Civitavecchia), Sorrento, Taormina (Naxos), Sicily, Chania (Souda), Crete, Santorini, Milos, Athens (Piraeus)
2026 Sails: Sep 12, More...

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Mediterranean Cruise Departures