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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Norwegian Cruise Line, Norwegian Viva
Norwegian Viva9 Night - Greek Isles & Italy
Starting in Istanbul, Turkey, Kusadasi, Turkey, Santorini Island, Greece, Mykonos, Greece, Piraeus / Athens, Greece, Olympia / Katakolon, Greece, Valletta, Malta, Catania, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Sep 7, More...
Royal Caribbean, Brilliance of the Seas
Brilliance of the Seas7 Night - Italy, Spain & French Riviera
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Santa Margherita, Italy, Cannes, France, Provence (Marseille), France, Valencia, Spain, Barcelona, Spain
2026 Sails: Sep 7, More...
Crystal Serenity7 Night - Europe & Mediterranean
Starting in Fusina (Venice), Trieste, Dubrovnik, Croatia, Corfu, Argostoli (Cephalonia), Monemvasia (Laconia), Athens (Piraeus)
2026 Sails: Sep 8, More...
MSC Cruises, MSC Musica
MSC Musica6 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy
2026 Sails: Sep 8, More...
Viking Sea7 Night - Italian Sojourn
Starting in Venice (Chioggia), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: Sep 8, More...
Viking Vesta7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Sep 8, More...
Atlas Ocean Voyages, World Traveller
World Traveller6 Night - Rome to Dubrovnik
Starting in Civitavecchia (Rome), Capri, Lipari (Aeolian Islands), Italy, Corfu, Kotor, Dubrovnik (Old Town)
2026 Sails: Sep 9, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa11 Night - Western Mediterranean from Athens (Pireo)
Starting in Piraeus (Athens), Malta / La Valletta, Catania, Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome), Ajaccio (Corsica), Savona
2026 Sails: Sep 9, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa13 Night - Western Mediterranean from Athens (Pireo)
Starting in Piraeus (Athens), Malta / La Valletta, Catania, Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome), Ajaccio (Corsica), Savona, Marseille, Barcelona
2026 Sails: Sep 9, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa12 Night - Western Mediterranean from Athens (Pireo)
Starting in Piraeus (Athens), Malta / La Valletta, Catania, Taranto, Malta / La Valletta, La Goulette (Tunis), Palermo, Naples, Civitavecchia (Rome), Ajaccio (Corsica), Savona, Marseille
2026 Sails: Sep 9, More...

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Mediterranean Cruise Departures