Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

Atlas Ocean Voyages, World Traveller

5 Night - Catania to Rome
Starting in Catania (Sicily), Amalfi (Ravello), Italy, Porto Cervo (Sardinia), Bonifacio (Corsica), Civitavecchia (Rome)
2026 Sails: Sep 4, More...

Avalon Waterways Tours, MS Farah Tours

9 Night - Taste of Egypt
Starting in Cairo, Egypt, Cairo, Cairo / Luxor (Embarkation), Luxor / Edfu, Edfu / Kom Ombo / Aswan, Aswan, Aswan (Disembarkation) Cairo, Cairo
2026 Sails: Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, More...

Costa Cruise Lines, Costa Fortuna

7 Night - Eastern Mediterranean from Athens (Pireo)
Starting in Piraeus (Athens), Istanbul, Mykonos, Heraklion (Crete), Rhodes, Thira (Santorini), Piraeus (Athens)
2026 Sails: Sep 4, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, More...

Viking River Tours, Viking Ra Tours

11 Night - Pharaohs & Pyramids
Starting in Cairo, Luxor, Qena, Luxor, Esna, Aswan, Kom Ombo, Edfu, Luxor, Cairo
2026 Sails: Sep 4, Sep 11, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, Nov 6, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 26, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Argostoli (Cephalonia), Dubrovnik, Croatia, Kotor, Zadar, Marghera (Venice)
2026 Sails: Sep 5, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome)
2026 Sails: Sep 5, More...

Emerald Cruises, Emerald Kaia

11 Night - Adriatic, Corinth Canal & the Greek Islands
Starting in Dubrovnik, Croatia, Korcula, Croatia, Kotor, Montenegro, Sarande, Albania, Corfu, Greece, Parga, Greece, Lefkada, Greece, Itea, Greece / Transit through the Corinth Canal, Mykonos, Greece, Paros, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 5, Oct 10, More...

Norwegian Line Tours, Norwegian Viva Tours

11 Night - Istanbul City Highlights Pre Cruisetour
Starting in At Hotel, Istanbul, Turkey, Kusadasi, Turkey, Santorini Island, Greece, Mykonos, Greece, Piraeus / Athens, Greece, Olympia / Katakolon, Greece, Valletta, Malta, Catania, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Sep 5, More...

Star Clippers, Star Flyer

14 Night - Grand Voyage : Athens to Athens
Starting in Piraeus (Port of Athens), Greece, Dikili, Turkey, Myrina / Limnos, Greece, Skiathos, Greece, Skopelos, Greece, Poros, Greece, Piraeus (Port of Athens), Greece, Morning Sailing Through Samos Strait, Kusadasi, Turkey (Optional Tour Ephesus), Patmos, Greece, Amorgos, Greece, Mykonos, Greece, Sifnos, Greece, Piraeus (Port of Athens), Greece
2026 Sails: Sep 5, More...

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Mediterranean Cruise Departures