Istanbul Cruise Departures
Cruises that depart from Mediterranean: Turkey: Istanbul
Cruises that visit Istanbul
See all River Cruises that depart from Istanbul
3 Night - Mediterranean
Starting in Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Jun 22, More...
22 Night - Byzantine, Barcelona & Belem
Starting in Istanbul, Mytilini (Lesbos), Kusadasi, Heraklion (Crete), Cruising the Ionian Sea, Dubrovnik, Croatia, Kotor, Corfu, Cruising the Ionian Sea, Valletta, Catania (Sicily), Sorrento / Capri, Rome (Civitavecchia), Tuscany (Livorno), Toulon, Barcelona, Palma De Mallorca, Cruising the Mediterranean Sea, Malaga, Gibraltar, Cruising the Atlantic Ocean, Portimao, Lisbon
2026 Sails: Jun 28, More...12 Night - Knights & Emperors
Starting in Istanbul, Mytilini (Lesbos), Kusadasi, Heraklion (Crete), Cruising the Ionian Sea, Dubrovnik, Croatia, Kotor, Corfu, Cruising the Ionian Sea, Valletta, Catania (Sicily), Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Jun 28, More...
7 Night - Turkey & Greek Isle Gems
Starting in Istanbul, Turkey, Canakkale, Turkey, Izmir, Turkey, Patmos, Greece, Rhodes, Greece, Spetses, Greece, Piraeus (Athens), Greece
2026 Sails: Jun 28, Oct 18, More...21 Night - Jewels of the Adriatic & Aegean
Starting in Istanbul, Turkey, Canakkale, Turkey, Izmir, Turkey, Patmos, Greece, Rhodes, Greece, Spetses, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Dubrovnik, Croatia, Hvar, Croatia, Zadar, Croatia, Piran, Slovenia, Fusina (Venice), Italy, Vodice (Sibenik), Croatia, Kotor, Montenegro, Scenic cruising Bay of Kotor, Corfu, Greece, Sami, Cephalonia, Greece, Nafplion, Greece, Piraeus (Athens), Greece
2026 Sails: Jun 28, More...14 Night - Jewels of the Adriatic & Aegean
Starting in Istanbul, Turkey, Canakkale, Turkey, Izmir, Turkey, Patmos, Greece, Rhodes, Greece, Spetses, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Dubrovnik, Croatia, Hvar, Croatia, Zadar, Croatia, Piran, Slovenia, Fusina (Venice), Italy
2026 Sails: Jun 28, More...
7 Night - Ancient Mediterranean Treasures
Starting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus)
2026 Sails: Jun 30, Aug 25, More...14 Night - Ancient Adriatic Treasures
Starting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus), Katakolon (Olympia), Corfu (Kerkyra), Kotor, Dubrovnik, Croatia, Split, Venice (Chioggia)
2026 Sails: Jun 30, More...28 Night - Mediterranean's Iconic Shores
Starting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus), Katakolon (Olympia), Corfu (Kerkyra), Kotor, Dubrovnik, Croatia, Split, Venice (Chioggia), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Jun 30, More...21 Night - Adriatic & Mediterranean Sojourn
Starting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus), Katakolon (Olympia), Corfu (Kerkyra), Kotor, Dubrovnik, Croatia, Split, Venice (Chioggia), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: Jun 30, More...
Cruises that depart from Mediterranean: Turkey: Istanbul
Cruises that visit Istanbul
See all River Cruises that depart from Istanbul
Click on a cruise ship itinerary sailing from Istanbul (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Istanbul), please visit: Cruise Search or try our Virtual Cruise Advisor™.
3 Night - MediterraneanStarting in Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Jun 22, More...
22 Night - Byzantine, Barcelona & BelemStarting in Istanbul, Mytilini (Lesbos), Kusadasi, Heraklion (Crete), Cruising the Ionian Sea, Dubrovnik, Croatia, Kotor, Corfu, Cruising the Ionian Sea, Valletta, Catania (Sicily), Sorrento / Capri, Rome (Civitavecchia), Tuscany (Livorno), Toulon, Barcelona, Palma De Mallorca, Cruising the Mediterranean Sea, Malaga, Gibraltar, Cruising the Atlantic Ocean, Portimao, Lisbon
2026 Sails: Jun 28, More...
12 Night - Knights & EmperorsStarting in Istanbul, Mytilini (Lesbos), Kusadasi, Heraklion (Crete), Cruising the Ionian Sea, Dubrovnik, Croatia, Kotor, Corfu, Cruising the Ionian Sea, Valletta, Catania (Sicily), Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Jun 28, More...
7 Night - Turkey & Greek Isle GemsStarting in Istanbul, Turkey, Canakkale, Turkey, Izmir, Turkey, Patmos, Greece, Rhodes, Greece, Spetses, Greece, Piraeus (Athens), Greece
2026 Sails: Jun 28, Oct 18, More...
21 Night - Jewels of the Adriatic & AegeanStarting in Istanbul, Turkey, Canakkale, Turkey, Izmir, Turkey, Patmos, Greece, Rhodes, Greece, Spetses, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Dubrovnik, Croatia, Hvar, Croatia, Zadar, Croatia, Piran, Slovenia, Fusina (Venice), Italy, Vodice (Sibenik), Croatia, Kotor, Montenegro, Scenic cruising Bay of Kotor, Corfu, Greece, Sami, Cephalonia, Greece, Nafplion, Greece, Piraeus (Athens), Greece
2026 Sails: Jun 28, More...
14 Night - Jewels of the Adriatic & AegeanStarting in Istanbul, Turkey, Canakkale, Turkey, Izmir, Turkey, Patmos, Greece, Rhodes, Greece, Spetses, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Dubrovnik, Croatia, Hvar, Croatia, Zadar, Croatia, Piran, Slovenia, Fusina (Venice), Italy
2026 Sails: Jun 28, More...
7 Night - Ancient Mediterranean TreasuresStarting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus)
2026 Sails: Jun 30, Aug 25, More...
14 Night - Ancient Adriatic TreasuresStarting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus), Katakolon (Olympia), Corfu (Kerkyra), Kotor, Dubrovnik, Croatia, Split, Venice (Chioggia)
2026 Sails: Jun 30, More...
28 Night - Mediterranean's Iconic ShoresStarting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus), Katakolon (Olympia), Corfu (Kerkyra), Kotor, Dubrovnik, Croatia, Split, Venice (Chioggia), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Jun 30, More...
21 Night - Adriatic & Mediterranean SojournStarting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus), Katakolon (Olympia), Corfu (Kerkyra), Kotor, Dubrovnik, Croatia, Split, Venice (Chioggia), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: Jun 30, More...
