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Istanbul Cruise Departures

Cruises that depart from Mediterranean: Turkey: Istanbul

Cruises that visit Istanbul

See all River Cruises that depart from Istanbul

Click on a cruise ship itinerary sailing from Istanbul (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Istanbul), please visit: Cruise Search or try our Virtual Cruise Advisor™.



AmaWaterways Tours, AmaMagna Tours
AmaMagna Tours12 Night - Gems of Southeast Europe with Istanbul Pre-Cruise and Vienna Post-Cruise
Starting in Istanbul, Giurgiu, Rousse, Vidin, Belgrade, Vukovar, Mohacs, Budapest, Vienna
2026 Sails: May 21, 2027: Mar 25, Apr 22, May 20, Jun 17, More...
Regent Seven Seas, Seven Seas Splendor
Seven Seas Splendor12 Night - Spring in the Aegean
Starting in Istanbul, Cruising the Aegean Sea, Kavala, Thessaloniki, Skiathos, Athens (Piraeus), Mykonos, Heraklion (Crete), Marmaris, Cruising the Aegean Sea, Izmir, Istanbul
2026 Sails: May 22, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Eastern Mediterranean from Istanbul
Starting in Istanbul, Izmir, Santorini, Mykonos, Volos, Athens (Piraeus), Istanbul
2026 Sails: May 24, More...
Explora Journeys, EXPLORA II
EXPLORA II11 Night - A Journey of Sunlight Island Idylls & Timeless Cities
Starting in Istanbul, Bodrum, Patmos, Piraeus (Athens), Paros, Rhodes, Corfu, Hvar, Rijeka, Fusina (Venice)
2026 Sails: May 28, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Eastern Mediterranean from Istanbul
Starting in Istanbul, Izmir, Volos, Mykonos, Santorini, Athens (Piraeus), Istanbul
2026 Sails: May 31, More...
Regent Seven Seas, Seven Seas Splendor
Seven Seas Splendor10 Night - Marvels of Antiquity
Starting in Istanbul, Bozcaada, Kusadasi, Cruising the Mediterranean Sea, Alexandria EG, Limassol, Rhodes, Santorini, Cruising the Aegean Sea, Athens (Piraeus)
2026 Sails: Jun 3, More...
Norwegian Cruise Line, Norwegian Viva
Norwegian Viva10 Night - Greek Isles & Italy
Starting in Istanbul, Turkey, Kusadasi, Turkey, Santorini Island, Greece, Mykonos, Greece, Piraeus / Athens, Greece, Olympia / Katakolon, Greece, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Zadar, Croatia, Venice (Ravenna), Italy
2026 Sails: Jun 5, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Eastern Mediterranean from Istanbul
Starting in Istanbul, Mykonos, Heraklion, Rhodes, Santorini, Athens (Piraeus), Istanbul
2026 Sails: Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, More...
Star Clippers, Star Flyer
Star Flyer7 Night - Yachtsman's Paradise
Starting in Istanbul, Turkey, Dikili, Turkey, Myrina / Limnos, Greece, Ouranoupoli, Greece, Skopelos, Greece, Poros, Greece, Piraeus (Port of Athens), Greece
2026 Sails: Jun 13, More...
Explora Journeys, EXPLORA II
EXPLORA II11 Night - A Journey from Byzantine Splendour to Venetian Grace
Starting in Istanbul, Kusadasi, Patmos, Piraeus (Athens), Paros, Rhodes, Corfu, Hvar, Rijeka, Fusina (Venice)
2026 Sails: Jun 18, More...

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Istanbul Cruise Departures