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Istanbul Cruise Departures

Cruises that depart from Mediterranean: Turkey: Istanbul

Cruises that visit Istanbul

See all River Cruises that depart from Istanbul

Click on a cruise ship itinerary sailing from Istanbul (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Istanbul), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Oceania Cruises, Oceania Allura
Oceania Allura10 Night - Aegean to Adriatic Passage
Starting in Istanbul, Bozcaada (Troy), Ephesus (Kusadasi), Athens (Piraeus), Santorini, Chania (Crete), Corfu, Dubrovnik, Croatia, Zadar, Trieste
2026 Sails: May 17, More...
Uniworld Tours, S.S. Joie de Vivre Tours
S.S. Joie de Vivre Tours14 Night - Cruise & Rail : Istanbul to Paris
Starting in Istanbul, Sofia, Belgrade, Postojna, Vienna, Vienna, Champagne, Paris, Paris, La Roche-Guyon, Vernon, Giverny, Rouen, Caudebec-en-Caux (Honfleur or Etretat), Rouen (Normandy Beaches), Mantes-la-Jolie (Versailles), Paris
2026 Sails: May 17, Sep 6, Oct 11, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna6 Night - Eastern Mediterranean from Istanbul
Starting in Istanbul, Izmir, Mykonos, Santorini, Athens (Piraeus), Istanbul
2026 Sails: May 18, More...
Norwegian Cruise Line, Norwegian Viva
Norwegian Viva9 Night - Greek Isles & Italy
Starting in Istanbul, Turkey, Kusadasi, Turkey, Mykonos, Greece, Piraeus / Athens, Greece, Santorini Island, Greece, Olympia / Katakolon, Greece, Valletta, Malta, Catania, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: May 18, More...
AmaWaterways Tours, AmaMagna Tours
AmaMagna Tours12 Night - Gems of Southeast Europe with Istanbul Pre-Cruise and Vienna Post-Cruise
Starting in Istanbul, Giurgiu, Rousse, Vidin, Belgrade, Vukovar, Mohacs, Budapest, Vienna
2026 Sails: May 21, 2027: Mar 25, Apr 22, May 20, Jun 17, More...
AmaWaterways Tours, AmaMagna Tours
AmaMagna Tours20 Night - Grand Danube Cruise with Istanbul Pre-Cruise and Prague Post-Cruise
Starting in Istanbul, Giurgiu, Rousse, Vidin, Belgrade, Ilok, Mohacs, Budapest, Bratislava, Vienna, Springdale, Linz, Passau, Vilshofen, Regensburg, Prague
2026 Sails: May 21, Nov 19, More...
Regent Seven Seas, Seven Seas Splendor
Seven Seas Splendor12 Night - Spring in the Aegean
Starting in Istanbul, Cruising the Aegean Sea, Kavala, Thessaloniki, Skiathos, Athens (Piraeus), Mykonos, Heraklion (Crete), Marmaris, Cruising the Aegean Sea, Izmir, Istanbul
2026 Sails: May 22, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Eastern Mediterranean from Istanbul
Starting in Istanbul, Izmir, Santorini, Mykonos, Volos, Athens (Piraeus), Istanbul
2026 Sails: May 24, More...
MSC Cruises, MSC Fantasia
MSC Fantasia9 Night - Mediterranean
Starting in Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey
2026 Sails: May 26, More...
Explora Journeys, EXPLORA II
EXPLORA II11 Night - A Journey of Sunlit Island Idylls & Timeless Cities
Starting in Istanbul, Bodrum, Patmos, Piraeus (Athens), Paros, Rhodes, Corfu, Hvar, Rijeka, Fusina (Venice)
2026 Sails: May 28, More...

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Istanbul Cruise Departures