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Istanbul Cruise Departures

Cruises that depart from Mediterranean: Turkey: Istanbul

Cruises that visit Istanbul

See all River Cruises that depart from Istanbul

Click on a cruise ship itinerary sailing from Istanbul (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Istanbul), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Explora Journeys, EXPLORA I
EXPLORA I4 Night - A Journey Through Enduring Culture & Island Grace
Starting in Istanbul, Cesme, Syros (Syra), Piraeus (Athens)
2026 Sails: Apr 20, More...
Emerald Cruises, Emerald Dawn
Emerald Dawn11 Night - Istanbul & Enchantment of Eastern Europe
Starting in Istanbul, Istanbul / Bucharest, Bucharest / Giurgiu, Rousse, Vidin, Donji Milanovac / Golubac, Belgrade, Vukovar, Ordas, Budapest
2026 Sails: Apr 21, More...
Viking Ocean, Viking Jupiter
Viking Jupiter7 Night - Ancient Mediterranean Treasures
Starting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus)
2026 Sails: Apr 22, 2028: Aug 19, More...
Viking Ocean, Viking Vesta
Viking Vesta7 Night - Ancient Mediterranean Treasures
Starting in Istanbul, Troy (Canakkale), Ephesus (Kusadasi), Rhodes, Crete (Heraklion), Athens (Piraeus)
2026 Sails: Apr 28, Jun 23, Aug 18, More...
Regent Seven Seas, Seven Seas Grandeur
Seven Seas Grandeur12 Night - Historic Lands
Starting in Istanbul, Dikili, Kusadasi, Athens (Piraeus), Mykonos, Cruising the Mediterranean Sea, Gythion, Argostoli (Cephalonia), Corfu, Kotor, Dubrovnik, Croatia, Cruising the Adriatic Sea, Venice (Trieste)
2026 Sails: May 5, More...
Explora Journeys, EXPLORA II
EXPLORA II11 Night - A Journey of Enchanting Mediterranean Discovery & Cultural Depth
Starting in Istanbul, Kusadasi, Mykonos, Piraeus (Athens), Paros, Rhodes, Corfu, Hvar, Rijeka, Fusina (Venice)
2026 Sails: May 7, More...
MSC Fantasia9 Night - Mediterranean
Starting in Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey
2026 Sails: May 8, Jun 4, Jun 13, Jul 10, Jul 28, Aug 6, Aug 15, Aug 24, Sep 2, Sep 11, Oct 8, Oct 17, Nov 4, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Eastern Mediterranean from Istanbul
Starting in Istanbul, Izmir, Mykonos, Santorini, Athens (Piraeus), Volos, Istanbul
2026 Sails: May 11, More...
Cunard Line, Queen Victoria
Queen Victoria7 Night - Istanbul and Greek Islands
Starting in Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain
2026 Sails: May 11, More...
MSC Cruises, MSC Fantasia
MSC Fantasia9 Night - Mediterranean
Starting in Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey
2026 Sails: May 17, More...

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Istanbul Cruise Departures