Istanbul Cruise Departures
Cruises that depart from Mediterranean: Turkey: Istanbul
Cruises that visit Istanbul
See all River Cruises that depart from Istanbul
25 Night - The Best of the Mediterranean
Starting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Santorini, Greece, Mykonos, Greece, Crete (Chania), Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Barcelona, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2027 Sails: Aug 4, More...
18 Night - The Best of the Mediterranean
Starting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Santorini, Greece, Mykonos, Greece, Crete (Chania), Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Barcelona, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2027 Sails: Aug 4, More...
7 Night - Istanbul to Athens Adventure
Starting in Istanbul, Turkey, Cruise the Dardanelles / Kepez, Turkey, Kusadasi, Turkey, Patmos, Greece, Delos, Greece / Mykonos, Greece, Santorini, Greece, Milos, Greece, Athens (Piraeus), Greece
2027 Sails: Aug 21, Oct 16, More...
21 Night - Mediterranean Mosaic : Turkey, Greece & Croatia
Starting in Istanbul, Turkey, Canakkale, Turkey, Volos, Greece, Patmos, Greece, Rhodes, Greece, Santorini, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Itea (Delphi), Greece, Corfu, Greece, Brindisi (Lecce), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Koper, Slovenia, Rijeka, Croatia, Zadar, Croatia, Split, Croatia, Kotor, Montenegro, Dubrovnik, Croatia
2027 Sails: Aug 21, More...
14 Night - Hidden Gems of Turkey, Ancient Greek Ports & Italy
Starting in Istanbul, Turkey, Canakkale, Turkey, Volos, Greece, Patmos, Greece, Rhodes, Greece, Santorini, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Itea (Delphi), Greece, Corfu, Greece, Brindisi (Lecce), Italy, Kotor, Montenegro, Dubrovnik, Croatia
2027 Sails: Aug 21, More...
7 Night - A Journey Through a Tapestry of Serenity & Island Delights
Starting in Istanbul, Marmaris, Patmos, Syros (Syra), Agios Nikolaos (Crete), Mykonos, Piraeus (Athens)
2027 Sails: Sep 13, More...
32 Night - The Best of the Mediterranean
Starting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Rhodes, Greece, Mykonos, Greece, Crete (Chania), Greece, Valletta, Malta, Sicily (Palermo), Italy, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Livorno (for Florence / Pisa), Italy, Corsica (Ajaccio), France, Sardinia (Alghero), Italy, Valletta, Malta, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Trieste (for Venice), Italy, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Chania), Greece, Santorini, Greece, Rhodes, Greece, Limassol, Cyprus, Kusadasi, Turkey (for Ephesus), Athens (Piraeus), Greece
2027 Sails: Sep 14, More...
21 Night - The Best of the Mediterranean
Starting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Rhodes, Greece, Mykonos, Greece, Crete (Chania), Greece, Valletta, Malta, Sicily (Palermo), Italy, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Livorno (for Florence / Pisa), Italy, Corsica (Ajaccio), France, Sardinia (Alghero), Italy, Valletta, Malta, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Trieste (for Venice), Italy
2027 Sails: Sep 14, More...
42 Night - The Best of the Mediterranean
Starting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Rhodes, Greece, Mykonos, Greece, Crete (Chania), Greece, Valletta, Malta, Sicily (Palermo), Italy, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Livorno (for Florence / Pisa), Italy, Corsica (Ajaccio), France, Sardinia (Alghero), Italy, Valletta, Malta, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Trieste (for Venice), Italy, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Chania), Greece, Santorini, Greece, Rhodes, Greece, Limassol, Cyprus, Kusadasi, Turkey (for Ephesus), Athens (Piraeus), Greece, Crete (Chania), Greece, Katakolon (for Olympia), Greece, Sicily (Messina), Italy, Valletta, Malta, Santorini, Greece, Mykonos, Greece, Kusadasi, Turkey (for Ephesus), Istanbul, Turkey
2027 Sails: Sep 14, More...
16 Night - Star Collector : Eternal Greece
Starting in Istanbul, Myrina (Lemnos), Mykonos, Kusadasi, Bodrum, Santorini, Delphi, Corinth Canal, Athens, Greece, Kusadasi, Kavala, Greece, Thessaloniki, Greece, Volos, Greece, Skopelos, Greece, Athens, Greece
2027 Sails: Sep 16, More...
Cruises that depart from Mediterranean: Turkey: Istanbul
Cruises that visit Istanbul
See all River Cruises that depart from Istanbul
Click on a cruise ship itinerary sailing from Istanbul (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Istanbul), please visit: Cruise Search or try our Virtual Cruise Advisor™.
25 Night - The Best of the MediterraneanStarting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Santorini, Greece, Mykonos, Greece, Crete (Chania), Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Barcelona, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2027 Sails: Aug 4, More...
18 Night - The Best of the MediterraneanStarting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Santorini, Greece, Mykonos, Greece, Crete (Chania), Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Barcelona, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2027 Sails: Aug 4, More...
7 Night - Istanbul to Athens AdventureStarting in Istanbul, Turkey, Cruise the Dardanelles / Kepez, Turkey, Kusadasi, Turkey, Patmos, Greece, Delos, Greece / Mykonos, Greece, Santorini, Greece, Milos, Greece, Athens (Piraeus), Greece
2027 Sails: Aug 21, Oct 16, More...
21 Night - Mediterranean Mosaic : Turkey, Greece & CroatiaStarting in Istanbul, Turkey, Canakkale, Turkey, Volos, Greece, Patmos, Greece, Rhodes, Greece, Santorini, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Itea (Delphi), Greece, Corfu, Greece, Brindisi (Lecce), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Koper, Slovenia, Rijeka, Croatia, Zadar, Croatia, Split, Croatia, Kotor, Montenegro, Dubrovnik, Croatia
2027 Sails: Aug 21, More...
14 Night - Hidden Gems of Turkey, Ancient Greek Ports & ItalyStarting in Istanbul, Turkey, Canakkale, Turkey, Volos, Greece, Patmos, Greece, Rhodes, Greece, Santorini, Greece, Piraeus (Athens), Greece, Gythion (Sparta), Greece, Itea (Delphi), Greece, Corfu, Greece, Brindisi (Lecce), Italy, Kotor, Montenegro, Dubrovnik, Croatia
2027 Sails: Aug 21, More...
7 Night - A Journey Through a Tapestry of Serenity & Island DelightsStarting in Istanbul, Marmaris, Patmos, Syros (Syra), Agios Nikolaos (Crete), Mykonos, Piraeus (Athens)
2027 Sails: Sep 13, More...
32 Night - The Best of the MediterraneanStarting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Rhodes, Greece, Mykonos, Greece, Crete (Chania), Greece, Valletta, Malta, Sicily (Palermo), Italy, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Livorno (for Florence / Pisa), Italy, Corsica (Ajaccio), France, Sardinia (Alghero), Italy, Valletta, Malta, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Trieste (for Venice), Italy, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Chania), Greece, Santorini, Greece, Rhodes, Greece, Limassol, Cyprus, Kusadasi, Turkey (for Ephesus), Athens (Piraeus), Greece
2027 Sails: Sep 14, More...
21 Night - The Best of the MediterraneanStarting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Rhodes, Greece, Mykonos, Greece, Crete (Chania), Greece, Valletta, Malta, Sicily (Palermo), Italy, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Livorno (for Florence / Pisa), Italy, Corsica (Ajaccio), France, Sardinia (Alghero), Italy, Valletta, Malta, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Trieste (for Venice), Italy
2027 Sails: Sep 14, More...
42 Night - The Best of the MediterraneanStarting in Istanbul, Turkey, Kusadasi, Turkey (for Ephesus), Rhodes, Greece, Mykonos, Greece, Crete (Chania), Greece, Valletta, Malta, Sicily (Palermo), Italy, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Livorno (for Florence / Pisa), Italy, Corsica (Ajaccio), France, Sardinia (Alghero), Italy, Valletta, Malta, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Trieste (for Venice), Italy, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Katakolon (for Olympia), Greece, Crete (Chania), Greece, Santorini, Greece, Rhodes, Greece, Limassol, Cyprus, Kusadasi, Turkey (for Ephesus), Athens (Piraeus), Greece, Crete (Chania), Greece, Katakolon (for Olympia), Greece, Sicily (Messina), Italy, Valletta, Malta, Santorini, Greece, Mykonos, Greece, Kusadasi, Turkey (for Ephesus), Istanbul, Turkey
2027 Sails: Sep 14, More...
16 Night - Star Collector : Eternal GreeceStarting in Istanbul, Myrina (Lemnos), Mykonos, Kusadasi, Bodrum, Santorini, Delphi, Corinth Canal, Athens, Greece, Kusadasi, Kavala, Greece, Thessaloniki, Greece, Volos, Greece, Skopelos, Greece, Athens, Greece
2027 Sails: Sep 16, More...