Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail:
Aare River : Amstel River : Cibin River : Corrib River : Dambovita River : Danube River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Moselle River : Neckar River : Ness River : Netherlands Waterways : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River

7 Night - Europe's Rivers & Castles
Starting in Luxembourg, Bernkastel, Cochem, Koblenz, Rudesheim, Wertheim, Wurzburg, Eltmann, Nuremberg
2026 Sails: Aug 26, Oct 21, More...

Avalon Waterways Tours, Avalon Vista Tours

17 Night - The Best of Austria & Switzerland with Romantic Rhine
Starting in Vienna, Austria, Vienna, Vienna / Mondsee / Salzburg, Salzburg, Salzburg / Innsbruck / St Moritz, Switzerland, St Moritz / Chur / Zermatt, Zermatt, Zermatt / Bern, Bern / Interlaken / Lucerne, Lucerne, Lucerne / Basel, Switzerland (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation)
2026 Sails: Aug 26, Sep 9, More...

Scenic Luxury, Scenic Jade

18 Night - Jewels of Europe with Ljubljana & Zagreb
Starting in Amsterdam, Cologne / Bonn, Rhine Gorge / Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau / Schlogen, Durnstein / Krems, Vienna, Budapest, Budapest / Ljubljana, Ljubljana, Ljubljana / Zagreb, Zagreb / Plitvice National Park / Zagreb, Zagreb
2026 Sails: Aug 26, More...

Scenic Luxury, Scenic Ruby

28 Night - Romantic Rhine & Moselle with Wonders of Switzerland & Austria
Starting in Amsterdam, Dordrecht, Bruinisse, Antwerp, Arnhem, Dusseldorf, Cochem, Bernkastel, Koblenz, Rudesheim, Mannheim, Strasbourg, Breisach, Basel (Huningue) / Zurich, Zurich, Zurich / Lucerne and Engelberg / Interlaken, Interlaken, Interlaken / Montreux, Montreux, Montreux / Zermatt, Zermatt, Zermatt / Schwangau, Schwangau, Schwangau / Salzburg, Salzburg, Salzburg / Vienna, Vienna
2026 Sails: Aug 26, More...

Scenic Luxury, Scenic Jasper

33 Night - Jewels of Europe with Majestic Britain & Ireland
Starting in Dublin, Dublin / Killarney, Killarney, Killarney / Galway, Galway / Belfast, Belfast, Belfast / Loch Lomond, Loch Lomond, Loch Lomond / Inverness, Inverness, Inverness / Edinburgh, Edinburgh, Edinburgh / York, York, York / Bath, Bath, Bath / London, London, London / Amsterdam, Amsterdam, Cologne / Bonn, Rhine Gorge / Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau / Schlogen, Durnstein / Krems, Vienna, Budapest
2026 Sails: Aug 27, More...

Uniworld Tours, S.S. Beatrice Tours

23 Night - Ultimate European Journey
Starting in Bucharest, Bucharest, Transfer to Giurgiu, Ruse, Vidin, Cruising the Iron Gates, Donji Milanovac, Golubac, Belgrade, Ilok, Aljmas, Budapest, Cruising the Danube River, Vienna, Vienna, Cruising the Wachau Valley, Weissenkirchen (Melk), Passau, Regensburg, Nuremberg, Bamberg, Wurzburg (Rothenburg), Wertheim, Frankfurt (Heidelberg), Rudesheim, Cologne, Amsterdam
2026 Sails: Aug 28, More...

Scenic Luxury, Scenic Jasper

17 Night - Jewels of Europe with Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam
2026 Sails: Aug 29, More...

AmaWaterways Tours, AmaCerto Tours

13 Night - Europe's Rivers & Castles with Prague Pre-Cruise and Paris Post-Cruise
Starting in Prague, Nuremberg, Bamberg, Wurzburg, Wertheim, Lahnstein, Cochem, Wasserbillig, Luxembourg, Paris
2026 Sails: Aug 30, Oct 25, 2027: Mar 28, May 9, Aug 29, Oct 10, More...

Emerald Cruises, Emerald Astra

7 Night - Legendary Rhine & Moselle
Starting in Frankfurt Airport / Mainz, Rudesheim, Bernkastel, Trier (Schweich), Cochem, Koblenz, Mainz, Mainz / Frankfurt
2026 Sails: Sep 1, Sep 8, More...

AmaWaterways, AmaCerto

7 Night - Europe's Rivers & Castles
Starting in Nuremberg, Bamberg, Wurzburg, Wertheim, Rudesheim, Lahnstein, Cochem, Wasserbillig, Luxembourg
2026 Sails: Sep 2, Oct 28, 2027: Mar 31, May 12, Sep 1, Oct 13, More...

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