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Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail: Aare River : Amstel River : Corrib River : Dambovita River : Danube River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River


AmaWaterways, AmaStella
AmaStella Cruises14 Night - Magnificent Europe
Starting in Amsterdam, Dusseldorf, Rudesheim, Wertheim, Wurzburg, Eltmann, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2026 Sails: May 2, More...
Emerald Cruises, Emerald Sun
Emerald Sun Cruises14 Night - Splendours of Europe
Starting in Amsterdam, Cologne, Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: May 2, Nov 4, 2027: Apr 23, Oct 4, Nov 1, More...
Emerald Cruises, Emerald Sun
Emerald Sun Cruises17 Night - Splendours of Europe & Prague
Starting in Amsterdam, Cologne, Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau, Melk / Durnstein, Vienna, Bratislava, Budapest, Budapest / Prague, Prague
2026 Sails: May 2, 2027: Oct 4, Nov 1, More...
Avalon Waterways, Avalon Tranquility II
Avalon Tranquility II Cruises8 Night - German Grandeur (Eastbound)
Starting in Basel, Switzerland (Embarkation), Breisach, Germany Excursion to Black Forest, Strasbourg, France, Rudesheim, Germany / Rhine Gorge, Frankfurt Excursion to Seligenstadt, Wertheim, Wurzburg, Bamberg, Nuremberg (Disembarkation)
2026 Sails: May 3, 2027: Oct 12, More...
Avalon Waterways, Avalon Tranquility II
Avalon Tranquility II Cruises15 Night - Enchanted Europe (Eastbound)
Starting in Basel, Switzerland (Embarkation), Breisach, Germany Excursion to Black Forest, Strasbourg, France, Rudesheim, Germany / Rhine Gorge, Frankfurt Excursion to Seligenstadt, Wertheim, Wurzburg, Bamberg, Nuremberg-excursion to Munich, Nuremberg, Regensburg, Passau, Melk / Wachau Valley, Vienna, Budapest, Hungary, Budapest (Disembarkation)
2026 Sails: May 3, 2027: Oct 12, More...
Avalon Waterways Cruise Tours, Avalon Tranquility II Cruise Tours
Avalon Tranquility II Cruises10 Night - German Grandeur with in Munich (Eastbound)
Starting in Basel, Switzerland (Embarkation), Breisach, Germany Excursion to Black Forest, Strasbourg, France, Rudesheim, Germany / Rhine Gorge, Frankfurt Excursion to Seligenstadt, Wertheim, Wurzburg, Bamberg, Nuremberg (Disembarkation) Munich, Munich
2026 Sails: May 3, 2027: Oct 12, More...
Viking River, Viking Gefjon
Viking Gefjon Cruises14 Night - Grand European Tour
Starting in Amsterdam, Kinderdijk, Scenic Sailing Waal and Merwede, Cologne, Koblenz, Middle Rhine Scenic Sailing, Miltenberg, Scenic Sailing Main River, Wurzburg, Bamberg, Main-Danube Canal, Nuremberg, Regensburg, Passau, Melk, Scenic Sailing Wachau Valley, Krems, Vienna, Budapest
2026 Sails: May 5, Jun 2, Jun 30, Jul 28, Aug 25, Sep 22, Oct 20, More...
Viking River, Viking Ve
Viking Ve Cruises14 Night - Grand European Tour
Starting in Budapest, Vienna, Scenic Sailing Wachau Valley, Melk, Passau, Regensburg, Main-Danube Canal, Nuremberg, Bamberg, Wurzburg, Wertheim, Scenic Sailing Main River, Middle Rhine Scenic Sailing, Koblenz, Cologne, Scenic Sailing Waal and Merwede, Kinderdijk, Amsterdam
2026 Sails: May 5, Jun 2, Jun 30, Jul 28, Aug 25, Sep 22, Oct 20, More...
Avalon Waterways Cruise Tours, Avalon Vista Cruise Tours
Avalon Vista Cruises17 Night - The Best of Austria & Switzerland with Romantic Rhine
Starting in Vienna, Austria, Vienna, Vienna / Mondsee / Salzburg, Salzburg, Salzburg / Innsbruck / St Moritz, Switzerland, St Moritz / Chur / Zermatt, Zermatt, Zermatt / Bern, Bern / Interlaken / Lucerne, Lucerne, Lucerne / Basel, Switzerland (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation)
2026 Sails: May 6, Jun 3, Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, More...
Viking River, Viking Lif
Viking Lif Cruises14 Night - Grand European Tour
Starting in Budapest, Vienna, Scenic Sailing Wachau Valley, Melk, Passau, Regensburg, Main-Danube Canal, Nuremberg, Bamberg, Wurzburg, Wertheim, Scenic Sailing Main River, Middle Rhine Scenic Sailing, Koblenz, Cologne, Scenic Sailing Waal and Merwede, Kinderdijk, Amsterdam
2026 Sails: May 6, Jun 17, Jul 29, Sep 9, Oct 21, 2027: Jun 16, Jul 28, Sep 8, Oct 20, More...

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Main River Cruises