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Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail: Aare River : Amstel River : Corrib River : Dambovita River : Danube River : Douro River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Manzanares River : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River


Emerald Cruises, Emerald Astra
Emerald Astra Cruises10 Night - Berlin & Legendary Rhine & Moselle
Starting in Berlin, Berlin / Frankfurt / Mainz, Rudesheim, Bernkastel, Trier (Schweich), Cochem, Koblenz, Mainz, Mainz / Frankfurt
2026 Sails: Sep 5, More...
Emerald Cruises, Emerald Luna
Emerald Luna Cruises17 Night - Splendours of Europe & Paris
Starting in Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam, Amsterdam / Paris, Paris
2026 Sails: Sep 5, Oct 17, 2027: Jul 24, Sep 18, More...
Uniworld Boutique River Cruise Collection, S.S. Beatrice
S.S. Beatrice Cruise Ship14 Night - European Jewels
Starting in Budapest, Cruising the Danube River, Vienna, Vienna, Cruising the Wachau Valley, Weissenkirchen (Melk), Passau, Regensburg, Nuremberg, Bamberg, Wurzburg (Rothenburg), Wertheim, Frankfurt (Heidelberg), Rudesheim, Cologne, Amsterdam
2026 Sails: Sep 6, More...
Emerald Cruises, Emerald Astra
Emerald Astra Cruises10 Night - Legendary Rhine & Moselle & Romantic Franconia & Bavaria
Starting in Frankfurt Airport / Mainz, Rudesheim, Bernkastel, Trier (Schweich), Cochem, Koblenz, Mainz, Mainz / Nuremberg, Nuremberg / Munich, Munich / Neuschwanstein, Munich
2026 Sails: Sep 8, More...
Scenic Luxury Cruises, Scenic Jewel
Scenic Jewel Cruises28 Night - Jewels of Europe with Wonders of Switzerland & Austria
Starting in Zurich, Zurich / Lucerne and Engelberg / Interlaken, Interlaken, Interlaken / Montreux, Montreux, Montreux / Zermatt, Zermatt, Zermatt / Schwangau, Schwangau, Schwangau / Salzburg, Salzburg, Salzburg / Vienna, Vienna, Vienna / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam
2026 Sails: Sep 9, More...
Emerald Cruises, Emerald Astra
Emerald Astra Cruises7 Night - The Majestic Rhine
Starting in Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel / Zurich
2026 Sails: Sep 15, More...
Emerald Cruises, Emerald Astra
Emerald Astra Cruises7 Night - The Majestic Rhine
Starting in Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel
2026 Sails: Sep 15, More...
Emerald Cruises, Emerald Astra
Emerald Astra Cruises10 Night - The Majestic Rhine & Lucerne - Zurich
Starting in Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel / Lucerne, Lucerne, Lucerne / Zurich, Zurich
2026 Sails: Sep 15, More...
Riviera River Cruises, MS Geoffrey Chaucer
MS Geoffrey Chaucer Cruises14 Night - Cruise the Heart of Europe
Starting in Budapest, Hungary, Bratislava, Slovakia, Vienna, Austria, Melk, Austria, Passau, Germany, Main-Danube Canal, Nuremberg, Germany, Main River, Wurzburg, Miltenberg, Germany, Rudesheim, Germany, Boppard, Germany, Koblenz, Germany, Cologne, Germany
2026 Sails: Sep 16, More...
Uniworld Boutique River Cruise Collection, S.S. Beatrice
S.S. Beatrice Cruise Ship14 Night - European Jewels
Starting in Amsterdam, Cologne, Rudesheim, Frankfurt (Heidelberg), Wertheim, Wurzburg, Cruising the Main River, Kitzingen (Rothenburg), Bamberg, Nuremberg, Cruising the Main-Danube Canal, Regensburg, Passau, Weissenkirchen (Melk), Tulln, Vienna, Budapest
2026 Sails: Sep 20, More...

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Main River Cruises