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Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail: Aare River : Amstel River : Corrib River : Dambovita River : Danube River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River


Emerald Cruises, Emerald Luna
Emerald Luna Cruises14 Night - Splendours of Europe
Starting in Amsterdam, Cologne, Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: Jun 27, Sep 19, Oct 31, 2027: Jun 26, Aug 7, Sep 4, Oct 30, More...
Emerald Cruises, Emerald Luna
Emerald Luna Cruises17 Night - Splendours of Europe & Prague
Starting in Amsterdam, Cologne, Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau, Melk / Durnstein, Vienna, Bratislava, Budapest, Budapest / Prague, Prague
2026 Sails: Jun 27, Sep 19, 2027: Jun 26, Aug 7, Sep 4, More...
Emerald Cruises, Emerald Sun
Emerald Sun Cruises7 Night - Legendary Rhine & Moselle
Starting in Frankfurt Airport / Mainz, Rudesheim, Bernkastel, Trier (Schweich), Cochem, Koblenz, Mainz, Mainz / Frankfurt
2026 Sails: Jun 27, Jul 4, 2027: Aug 2, Aug 9, Aug 30, More...
AmaWaterways Cruise Tours, AmaCerto Cruise Tours
AmaCerto Cruise Tours13 Night - Europe's Rivers & Castles with Paris Pre-Cruise and Prague Post-Cruise
Starting in Paris, Luxembourg, Bernkastel, Cochem, Koblenz, Rhine Gorge, Rudesheim, Wertheim, Wurzburg, Nuremberg, Prague
2026 Sails: Jun 28, Aug 23, Oct 18, More...
Scenic Luxury Cruises, Scenic Jewel
Scenic Jewel Cruises20 Night - Jewels of Europe with Prague & Paris
Starting in Prague, Prague / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam, Amsterdam / Paris, Paris
2026 Sails: Jun 28, 2027: Sep 21, More...
Scenic Luxury Cruises, Scenic Jewel
Scenic Jewel Cruises17 Night - Jewels of Europe with Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam
2026 Sails: Jun 28, Oct 18, 2027: May 4, Sep 21, More...
Scenic Luxury Cruises, Scenic Opal
Scenic Opal Cruises23 Night - Jewels of Europe with Eastern Europe Explorer
Starting in Prague, Prague / Dresden / Berlin, Berlin, Berlin / Warsaw, Warsaw, Warsaw / Krakow, Krakow, Krakow / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam
2026 Sails: Jun 28, Aug 9, Sep 6, More...
Riviera River Cruises, MS Emily Bronte
MS Emily Bronte Cruises10 Night - Rhine Cruise to Switzerland (Including Glacier Express Extension)
Starting in Zermatt, Switzerland, Davos, Switzerland, Basel, Switzerland, Rhine River, Speyer, Germany, Rudesheim, Germany, Koblenz, Germany, Rhine River, Cologne, Germany
2026 Sails: Jun 29, 2027: May 7, Sep 3, More...
Riviera River Cruises, MS William Wordsworth
MS William Wordsworth Cruises14 Night - Cruise the Heart of Europe
Starting in Budapest, Hungary, Bratislava, Slovakia, Vienna, Austria, Melk, Austria, Passau, Germany, Main-Danube Canal, Nuremberg, Germany, Main River, Wurzburg, Miltenberg, Germany, Rudesheim, Germany, Boppard, Germany, Koblenz, Germany, Cologne, Germany
2026 Sails: Jun 29, More...
Emerald Cruises, Emerald Destiny
Emerald Destiny Cruises17 Night - Paris & Splendours of Europe
Starting in Paris, Paris / Amsterdam, Amsterdam, Cologne, Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: Jun 30, More...

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Main River Cruises