South America River Cruises
River Cruises that visit South America
River Cruises by region
See all South America Cruises
River cruises by river name
Related areas: Brazil : Colombia : Ecuador : Peru
7 Night - Wonders of Colombia
Starting in Cartagena CO, Palenque, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Apr 11, Apr 25, May 9, Jun 6, Jun 20, Jul 4, Jul 18, Aug 29, Sep 12, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 19, 2027: May 22, More...10 Night - Wonders of Colombia with in Panama City Post Cruise
Starting in Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: Apr 11, Apr 25, May 9, Jun 6, Jun 20, Jul 4, Jul 18, Aug 29, Sep 12, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, 2027: May 22, More...
8 Night - Upper Amazon : a River Expedition
Starting in Lima, Peru, Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Apr 11, Apr 18, Apr 25, May 16, Jun 20, Jun 27, Jul 18, Jul 25, Aug 1, Aug 8, Sep 5, Sep 19, Sep 26, Oct 3, Oct 17, Nov 14, Dec 5, Dec 12, Dec 19, 2027: Jan 9, Jan 16, Jan 23, Mar 13, Mar 20, More...
10 Night - Magic of Colombia with Medellin Pre Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia
2026 Sails: Apr 12, Apr 26, May 10, May 24, Jun 7, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, Oct 25, Nov 8, Nov 22, Dec 6, More...13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 12, Apr 26, May 10, May 24, Jun 7, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, Oct 25, Nov 8, Nov 22, Dec 6, More...7 Night - Magic of Colombia
Starting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Palenque, Cartagena CO
2026 Sails: Apr 15, Apr 29, May 13, May 27, Jun 10, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 28, Nov 11, Nov 25, Dec 9, More...10 Night - Magic of Colombia with Medellin Pre Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia
2026 Sails: Apr 15, Apr 29, May 27, Jun 10, Jun 24, Jul 8, Aug 19, Sep 2, Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, Dec 23, More...13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post Cruise
Starting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 15, Apr 29, May 27, Jun 10, Jun 24, Jul 8, Aug 19, Sep 2, Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, Dec 23, More...10 Night - Magic of Colombia with Panama Post Cruise
Starting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 15, Apr 29, May 13, May 27, Jun 10, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 28, Nov 11, Nov 25, Dec 9, More...
9 Night - Exploring Peru : Machu Picchu and the Amazon
Starting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Apr 23, May 21, Jun 4, Jul 23, Aug 13, Aug 20, Sep 10, Nov 5, Nov 26, Dec 3, More...
River Cruises that visit South America
River Cruises by region
See all South America Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Related areas: Brazil : Colombia : Ecuador : Peru
7 Night - Wonders of ColombiaStarting in Cartagena CO, Palenque, Calamar, Magangue, Mompox, Santa Barbara de Pinto, Sitionuevo, Barranquilla
2026 Sails: Apr 11, Apr 25, May 9, Jun 6, Jun 20, Jul 4, Jul 18, Aug 29, Sep 12, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 19, 2027: May 22, More...
10 Night - Wonders of Colombia with in Panama City Post CruiseStarting in Cartagena CO, Colombia, Manzini, Calamar, Magangue, Mompox, San Felipe, Barranquilla, Panama City
2026 Sails: Apr 11, Apr 25, May 9, Jun 6, Jun 20, Jul 4, Jul 18, Aug 29, Sep 12, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, 2027: May 22, More...
8 Night - Upper Amazon : a River ExpeditionStarting in Lima, Peru, Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Apr 11, Apr 18, Apr 25, May 16, Jun 20, Jun 27, Jul 18, Jul 25, Aug 1, Aug 8, Sep 5, Sep 19, Sep 26, Oct 3, Oct 17, Nov 14, Dec 5, Dec 12, Dec 19, 2027: Jan 9, Jan 16, Jan 23, Mar 13, Mar 20, More...
10 Night - Magic of Colombia with Medellin Pre CruiseStarting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia
2026 Sails: Apr 12, Apr 26, May 10, May 24, Jun 7, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, Oct 25, Nov 8, Nov 22, Dec 6, More...
13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post CruiseStarting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 12, Apr 26, May 10, May 24, Jun 7, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, Oct 25, Nov 8, Nov 22, Dec 6, More...
Deal link -> Special
7 Night - Magic of ColombiaStarting in Barranquilla, Sitionuevo, Magangue, Mompox, Santa Barbara de Pinto, Calamar, Palenque, Cartagena CO
2026 Sails: Apr 15, Apr 29, May 13, May 27, Jun 10, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 28, Nov 11, Nov 25, Dec 9, More...
10 Night - Magic of Colombia with Medellin Pre CruiseStarting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia
2026 Sails: Apr 15, Apr 29, May 27, Jun 10, Jun 24, Jul 8, Aug 19, Sep 2, Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, Dec 23, More...
13 Night - Magic of Colombia with in Medellin Pre Cruise and in Panama City Post CruiseStarting in Medellin, Barranquilla, Medellin, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 15, Apr 29, May 27, Jun 10, Jun 24, Jul 8, Aug 19, Sep 2, Sep 30, Oct 14, Oct 28, Nov 11, Nov 25, Dec 9, Dec 23, More...
10 Night - Magic of Colombia with Panama Post CruiseStarting in Barranquilla, San Felipe, Magangue, Mompox, Calamar, Manzini, Cartagena CO, Colombia, Panama City
2026 Sails: Apr 15, Apr 29, May 13, May 27, Jun 10, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 28, Nov 11, Nov 25, Dec 9, More...
9 Night - Exploring Peru : Machu Picchu and the AmazonStarting in Lima, Peru, Lima / Cusco / Sacred Valley, Machu Picchu, Sacred Valley / Cusco, Cusco, Cusco / Lima / Iquitos / Nauta / Embark Ship, Pacaya-Samiria Reserve, Nauta / Disembark Ship / Iquitos / Lima
2026 Sails: Apr 23, May 21, Jun 4, Jul 23, Aug 13, Aug 20, Sep 10, Nov 5, Nov 26, Dec 3, More...
